Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2022/203219
Kind Code:
A1
Abstract:
The present invention relates to a novel oligopeptide AQTGTGKT analog compound and, more specifically, provides an analog compound of the oligopeptide AQTGTGKT, which exhibits an excellent anticancer effect and is stably present in human blood, a pharmaceutical composition comprising same as an active ingredient, and a preparation method therefor. Exhibiting the effects of further inhibiting the proliferation of cancer cells and being stably present in human blood in addition to having a lower risk of immune reactions and penetrating into tissues with ease because of the lower molecular weight than an antibody, which is an advantage possessed by an oligopeptide formulation, the analog compound and the pharmaceutical composition comprising same as an active ingredient according to the present invention can be used as an anticancer agent useful for treating cancer.
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Inventors:
JEON DO YONG (KR)
Application Number:
PCT/KR2022/002762
Publication Date:
September 29, 2022
Filing Date:
February 25, 2022
Export Citation:
Assignee:
L BASE CO LTD (KR)
International Classes:
C07K7/06; A61K38/08; A61P35/00; C07K1/00
Domestic Patent References:
| WO2016099188A1 | 2016-06-23 |
Foreign References:
| JP2020505326A | 2020-02-20 | |||
| KR20120099440A | 2012-09-10 | |||
| KR20210118764A | 2021-10-01 |
Other References:
MINJEONG YEON, JAEWHAN BYUN, HYUNA KIM, MISUN KIM, HYUN SUK JUNG, DOYONG JEON, YOUNGMI KIM, DOOIL JEOUNG: "CAGE Binds to Beclin1, Regulates Autophagic Flux and CAGE-Derived Peptide Confers Sensitivity to Anti-cancer Drugs in Non-small Cell Lung Cancer Cells", FRONTIERS IN ONCOLOGY, vol. 8, XP055756617, DOI: 10.3389/fonc.2018.00599
YOUNGMI KIM, HYUNA KIM, DEOKBUM PARK, HANSOO LEE, YUN SIL LEE, JONGSEON CHOE, YOUNG MYEONG KIM, DOYONG JEON, DOOIL JEOUNG: "The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3β and decreasing the expression of cyclinD1", ONCOTARGET, vol. 8, no. 8, 21 February 2017 (2017-02-21), pages 13632 - 13651, XP055756625, DOI: 10.18632/oncotarget.14621
YOUNGMI KIM, HYUNA KIM, DEOKBUM PARK, HANSOO LEE, YUN SIL LEE, JONGSEON CHOE, YOUNG MYEONG KIM, DOYONG JEON, DOOIL JEOUNG: "The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3β and decreasing the expression of cyclinD1", ONCOTARGET, vol. 8, no. 8, 21 February 2017 (2017-02-21), pages 13632 - 13651, XP055756625, DOI: 10.18632/oncotarget.14621
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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