Title:
PHARMACEUTICAL COMPOSITION FOR SUPPRESSING PAIN
Document Type and Number:
WIPO Patent Application WO/2011/018902
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition for suppressing pain in joint disorders, said composition comprising a pharmaceutically allowable carrier and hyaluronic acid crosslinked by means of cyclizing a double bond of the cinnamic acid portion of a partially amidated hyaluronic acid represented by general formula 1, [Ar-CH=CH-COO-(CH2)n-NH-]m-HA (wherein Ar represents a phenyl group that may have substituent groups, n represents 2 or 3, HA represents a carboxyl residue of hyaluronic acid, m represents the proportion of amidated carboxyl groups out of all of the carboxyl groups of hyaluronic acid, and m is 3-50% of all of the carboxyl groups), forming a cyclobutane ring. The pharmaceutical composition is an intra-articularly administered formulation that, after administration, has a rapid analgesic effect, and unlike the conventional plurality of administrations, with only one administration, sustains an extremely long-term effect on human joint disorders.
Inventors:
HOSOKAWA HIROYUKI (JP)
LIM SOOYEOL (JP)
ODA JUNKO (JP)
LIM SOOYEOL (JP)
ODA JUNKO (JP)
Application Number:
PCT/JP2010/005060
Publication Date:
February 17, 2011
Filing Date:
August 13, 2010
Export Citation:
Assignee:
SEIKAGAKU KOGYO CO LTD (JP)
HOSOKAWA HIROYUKI (JP)
LIM SOOYEOL (JP)
ODA JUNKO (JP)
HOSOKAWA HIROYUKI (JP)
LIM SOOYEOL (JP)
ODA JUNKO (JP)
International Classes:
A61K31/728; A61K9/08; A61P19/02; A61P29/00
Domestic Patent References:
| WO2008069348A1 | 2008-06-12 | |||
| WO2008069348A1 | 2008-06-12 |
Foreign References:
| JPH0673102A | 1994-03-15 | |||
| JPH08143604A | 1996-06-04 | |||
| JPH11512778A | 1999-11-02 | |||
| US20060148755A1 | 2006-07-06 | |||
| JP2002249501A | 2002-09-06 |
Other References:
See also references of EP 2465512A4
THE JOURNAL OF RHEUMATOLOGY, vol. 31, no. 4, 2004, pages 775 - 782
CURRENT MEDICAL RESEARCH AND OPINION, vol. 11, 1988, pages 205 - 213
ARD ONLINE FIRST, 19 March 2009 (2009-03-19)
OSTEOARTHRITIS AND CARTILAGE, vol. 12, 2004, pages 642 - 649
ARTHRITIS & RHEUMATISM, vol. 43, no. 9, 2000, pages 1905 - 1915
THE JOURNAL OF RHEUMATOLOGY, vol. 15, no. 12, 1988, pages 1833 - 1840
THE JOURNAL OF RHEUMATOLOGY, vol. 27, no. 11, 2000, pages 2635 - 2641
THE JOURNAL OF RHEUMATOLOGY, vol. 31, no. 4, 2004, pages 775 - 782
CURRENT MEDICAL RESEARCH AND OPINION, vol. 11, 1988, pages 205 - 213
ARD ONLINE FIRST, 19 March 2009 (2009-03-19)
OSTEOARTHRITIS AND CARTILAGE, vol. 12, 2004, pages 642 - 649
ARTHRITIS & RHEUMATISM, vol. 43, no. 9, 2000, pages 1905 - 1915
THE JOURNAL OF RHEUMATOLOGY, vol. 15, no. 12, 1988, pages 1833 - 1840
THE JOURNAL OF RHEUMATOLOGY, vol. 27, no. 11, 2000, pages 2635 - 2641
Attorney, Agent or Firm:
SAEKI, NORIO (JP)
Norio Saeki (JP)
Norio Saeki (JP)
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