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Title:
PHARMACEUTICAL COMPOSITION FOR TREATING NON-HODGKIN'S LYMPHOMA
Document Type and Number:
WIPO Patent Application WO/2019/218810
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition for treating non-Hodgkin's lymphoma, comprising a protein kinase C inhibitor and rituximab. Also disclosed is a pharmaceutical composition for treating non-Hodgkin's lymphoma, comprising a first preparation formed by a protein kinase C inhibitor and a pharmaceutically acceptable carrier, and a second preparation formed by rituximab and a pharmaceutically acceptable carrier. By combining the discovery that PKC is highly phosphorylated in rituximab-resistant non-Hodgkin's lymphoma cells, and the principle of pro-apoptotic effects of a PKC inhibitor, the present invention proves, by means of researches, that the protein kinase C inhibitor can be used, alone or in combination with rituximab, for treating rituximab-tolerant relapsed/refractory non-Hodgkin's lymphoma and significantly improves the overall survival.

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Inventors:
HU WEIGUO (CN)
Application Number:
PCT/CN2019/082102
Publication Date:
November 21, 2019
Filing Date:
April 10, 2019
Export Citation:
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Assignee:
FUNDAN UNIV SHANGHAI CANCER CENTER (CN)
International Classes:
A61K45/06; A61K39/395; A61P35/00
Domestic Patent References:
WO2018045240A12018-03-08
Foreign References:
CN102821759A2012-12-12
Attorney, Agent or Firm:
SHANGHAI RONGHUI PATENT AGENCY (CN)
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