Title:
PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING AT LEAST ONE DISEASE SELECTED FROM GROUP CONSISTING OF INFLAMMATORY BOWEL DISEASE AND INTESTINAL TUMOR
Document Type and Number:
WIPO Patent Application WO/2023/140385
Kind Code:
A1
Abstract:
A pharmaceutical composition for treating or preventing at least one disease selected from the group consisting of inflammatory bowel disease and intestinal tumor, said pharmaceutical composition comprising an inhibitor for the binding of a dendritic cell immunoreceptor to a double-stranded asialo N-type sugar chain or a dendritic cell immunoreceptor inhibitor together with a pharmaceutically acceptable carrier.
Inventors:
IWAKURA YOICHIRO (JP)
CHUNG SOO-HYUN (JP)
KUBO MASATO (JP)
SUN HAIYANG (JP)
YABE RIKIO (JP)
CHUNG SOO-HYUN (JP)
KUBO MASATO (JP)
SUN HAIYANG (JP)
YABE RIKIO (JP)
Application Number:
PCT/JP2023/001986
Publication Date:
July 27, 2023
Filing Date:
January 23, 2023
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
A61K45/00; A61K39/395; A61P1/04; A61P35/00; C07K16/28
Domestic Patent References:
| WO2021100756A1 | 2021-05-27 | |||
| WO2016006700A1 | 2016-01-14 |
Other References:
SUMIKA TOKIEDA;MARIE KOMORI;TOSHIFUMI ISHIGURO;YOICHIRO IWAKURA;KAZUHIKO TAKAHARA;KAYO INABA: "Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis", BMC IMMUNOLOGY, BIOMED CENTRAL, LONDON, GB, vol. 16, no. 1, 23 October 2015 (2015-10-23), GB , pages 64, XP021230745, ISSN: 1471-2172, DOI: 10.1186/s12865-015-0129-5
KAIFU TOMONORI, YABE RIKIO, MARUHASHI TAKUMI, CHUNG SOO-HYUN, TATENO HIROAKI, FUJIKADO NORIYUKI, HIRABAYASHI JUN, IWAKURA YOICHIRO: "DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis", JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 218, no. 12, 6 December 2021 (2021-12-06), US , XP093078248, ISSN: 0022-1007, DOI: 10.1084/jem.20210435
FUJIKADO, NORIYUKI; IWAKURA, YOICHIRO : "Role of DCIR in autoimmune diseases", EXPERIMENTAL MEDICINE, YODOSHA CO., LTD., JP, vol. 26, no. 20, Suppl., 1 January 2008 (2008-01-01), JP , pages 3298 - 3303, XP009547629, ISSN: 0288-5514
SUN HAIYANG, TANG CE, CHUNG SOO-HYUN, YE XIAO-QI, MAKUSHEVA YULIA, HAN WEI, KUBO MASATO, SHICHINO SHIGEYUKI, UEHA SATOSHI, MATSUSH: "Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway", CELL REPORTS, ELSEVIER INC, US, vol. 40, no. 5, 1 August 2022 (2022-08-01), US , pages 111158, XP093078249, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2022.111158
KAIFU TOMONORI, YABE RIKIO, MARUHASHI TAKUMI, CHUNG SOO-HYUN, TATENO HIROAKI, FUJIKADO NORIYUKI, HIRABAYASHI JUN, IWAKURA YOICHIRO: "DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis", JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 218, no. 12, 6 December 2021 (2021-12-06), US , XP093078248, ISSN: 0022-1007, DOI: 10.1084/jem.20210435
FUJIKADO, NORIYUKI; IWAKURA, YOICHIRO : "Role of DCIR in autoimmune diseases", EXPERIMENTAL MEDICINE, YODOSHA CO., LTD., JP, vol. 26, no. 20, Suppl., 1 January 2008 (2008-01-01), JP , pages 3298 - 3303, XP009547629, ISSN: 0288-5514
SUN HAIYANG, TANG CE, CHUNG SOO-HYUN, YE XIAO-QI, MAKUSHEVA YULIA, HAN WEI, KUBO MASATO, SHICHINO SHIGEYUKI, UEHA SATOSHI, MATSUSH: "Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway", CELL REPORTS, ELSEVIER INC, US, vol. 40, no. 5, 1 August 2022 (2022-08-01), US , pages 111158, XP093078249, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2022.111158
Attorney, Agent or Firm:
TAIYO, NAKAJIMA & KATO (JP)
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