Title:
PHARMACEUTICAL COMPOSITION FOR TREATING TUMORS
Document Type and Number:
WIPO Patent Application WO/2023/190748
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for treating tumors, which comprises (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide represented by formula (I) or a pharmaceutically acceptable salt thereof and is administered in combination with an RAS inhibitor.
Inventors:
KATO YU (JP)
KUME MASAHIKO (JP)
HORI YUSAKU (JP)
ADACHI YUSUKE (JP)
KUME MASAHIKO (JP)
HORI YUSAKU (JP)
ADACHI YUSUKE (JP)
Application Number:
PCT/JP2023/012957
Publication Date:
October 05, 2023
Filing Date:
March 29, 2023
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
A61K31/53; A61K31/519; A61K45/00; A61P35/00; A61P43/00
Domestic Patent References:
| WO2015098853A1 | 2015-07-02 | |||
| WO2022031952A2 | 2022-02-10 |
Other References:
LUCA MOLOGNI, STEFANIA BRUSSOLO, MONICA CECCON, CARLO GAMBACORTI-PASSERINI: "Synergistic Effects of Combined Wnt/KRAS Inhibition in Colorectal Cancer Cells", PLOS ONE, vol. 7, no. 12, pages e51449, XP055200401, DOI: 10.1371/journal.pone.0051449
TURCIOS LILIA, VILCHEZ VALERY, ACOSTA LUIS F., POYIL PRATHEESHKUMAR, BUTTERFIELD DAVID ALLAN, MITOV MIHAIL, MARTI FRANCESC, GEDALY: "Sorafenib and FH535 in combination act synergistically on hepatocellular carcinoma by targeting cell bioenergetics and mitochondrial function", DIGESTIVE AND LIVER DISEASE, W.B. SAUNDERS, GB, vol. 49, no. 6, 1 June 2017 (2017-06-01), GB , pages 697 - 704, XP055787452, ISSN: 1590-8658, DOI: 10.1016/j.dld.2017.01.146
TURCIOS LILIA, VILCHEZ VALERY, ACOSTA LUIS F., POYIL PRATHEESHKUMAR, BUTTERFIELD DAVID ALLAN, MITOV MIHAIL, MARTI FRANCESC, GEDALY: "Sorafenib and FH535 in combination act synergistically on hepatocellular carcinoma by targeting cell bioenergetics and mitochondrial function", DIGESTIVE AND LIVER DISEASE, W.B. SAUNDERS, GB, vol. 49, no. 6, 1 June 2017 (2017-06-01), GB , pages 697 - 704, XP055787452, ISSN: 1590-8658, DOI: 10.1016/j.dld.2017.01.146
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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