Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF 2 TYPE DABETES
Document Type and Number:
WIPO Patent Application WO/2010/111905
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for the treatment of 2 type diabetes, wherein the pharmaceutical composition contains (R)-7-[3-amino- 4-(2,4,5-trifluoro-phenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid methyl ester or its pharmaceutically acceptable salts and metformin or its pharmaceutically acceptable salts (such as hydrochlorate), preparation method thereof and method of treating 2 type diabetes with the composition.
Inventors:
YUAN KAIHONG (CN)
SUN PIAOYANG (CN)
SUN PIAOYANG (CN)
Application Number:
PCT/CN2010/070910
Publication Date:
October 07, 2010
Filing Date:
March 08, 2010
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
YUAN KAIHONG (CN)
SUN PIAOYANG (CN)
YUAN KAIHONG (CN)
SUN PIAOYANG (CN)
International Classes:
C07D487/04; A61K9/20; A61K31/155; A61K31/495; A61K31/4985; A61P3/10
Foreign References:
| CN101277719A | 2008-10-01 | |||
| CN1391890A | 2003-01-22 | |||
| CN1478770A | 2004-03-03 |
Other References:
HANS-ULRICH DEMUTH ET AL.: "Type 2 diabetes-Therapy with dipeptidyl peptidase IV inhibitors", BIOCHIMICA ET BIOPHYSICAACTA, vol. 1751, 2005, pages 33 - 44, XP027627872
See also references of EP 2402342A4
H. -U. DEMUTH. ET AL.: "Type 2 diabetes-Therapy with dipeptidyl peptidase IV inhibitors", BIOCHIM. BIOPHVS. ACTA, vol. 1751, 2005, pages 33 - 44
K. AUGUSTYNS. ET AL.: "Inhibitors of proline-specific dipeptidyl peptidases: DPP4 inhibitors as a novel approach for the treatment of Type 2 diabetes", EXPERT OPIN. THER. PATANTS, vol. 15, 2005, pages 1387 - 1407
See also references of EP 2402342A4
H. -U. DEMUTH. ET AL.: "Type 2 diabetes-Therapy with dipeptidyl peptidase IV inhibitors", BIOCHIM. BIOPHVS. ACTA, vol. 1751, 2005, pages 33 - 44
K. AUGUSTYNS. ET AL.: "Inhibitors of proline-specific dipeptidyl peptidases: DPP4 inhibitors as a novel approach for the treatment of Type 2 diabetes", EXPERT OPIN. THER. PATANTS, vol. 15, 2005, pages 1387 - 1407
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (Tower E3 The Towers, Oriental Plaza,No.1, East Chang An Avenue, Dongcheng District, Beijing 8, CN)
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