PHARMACEUTICAL COMPOSITION AND TREATMENT AGENT

WIPO Patent Application WO/2021/117769

A1

The present invention addresses the problem of providing: a pharmaceutical composition in which are combined a novel artificial match-type miRNA utilizing miRNA, and a lipid having excellent nucleic acid delivery capability; and a treatment agent. According to the present invention, provided is a pharmaceutical composition containing an artificial match-type miRNA, a lipid that is a compound represented by formula (1) or is a salt thereof, a nonionic lipid, and a lipid having a nonionic hydrophilic polymer structure. The artificial match-type miRNA contains a nucleic acid molecule composed of the base sequence represented by sequence A below. (Sequence A) 5'-UAGCACCAUUUGAAAUCAGUGUU-P-AACACUGAUUUCAAAUGGUGCUAGA-3' In the formula, P indicates a prescribed linker. X, R2-R12, a, b, c, and d in the formula have the meanings defined in the specification of the present application.

JP2001513992	INDUSTRIAL APPLICABILITY: A novel tissue-specific calpain, its production and its use.
JP6914860	Cationic mucic acid polymer delivery system
WO/2018/216792	AGENT FOR IMPROVING STABILITY OF RNA IN BLOOD, AND ADMINISTRATION METHOD

ENDO TAISUKE (JP)
IMOTO JUNICHI (JP)
FUNASE YUICHI (JP)

PCT/JP2020/045874

June 17, 2021

December 09, 2020

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FUJIFILM CORP (JP)

A61K31/7105; A61K47/18; A61K47/28; A61K47/34; A61K47/44; A61P1/16; A61P43/00; C12N15/113

WO2015095340A1	2015-06-25
WO2015095346A1	2015-06-25
WO2018155487A1	2018-08-30

JP2012530059A

2012-11-29

SIKS & CO. (JP)

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