Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CORONAVIRUS DISEASES AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/203614
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for the treatment of coronavirus diseases, a preparation method therefor, and application thereof. The pharmaceutical composition contains a first Chinese herbal medicine extract and a second Chinese herbal medicine extract as active ingredients, the first Chinese medicinal extract being water or alcohol extracts of ephedra, bitter almond, raw gypsum, coix seed, atractylodes, patchouli, polygonum cuspidatum, verbena, reed root, lepidium seed, pummelo peel, and sweet wormwood, and the second Chinese herbal medicine extract being the water or alcohol extract of licorice. The pharmaceutical composition per ten grams contains not less than 2.3 mg of ephedrine hydrochloride and pseudoephedrine hydrochloride in total, not less than 42.7 mg of naringin, and not less than 7.7 mg of glycyrrhizic acid. The pharmaceutical composition of the present invention can be used for treatment of diseases caused by coronaviruses.
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Inventors:
ZHANG BOLI (CN)
LIU QINGQUAN (CN)
GAO XIUMEI (CN)
ZHANG JUNHUA (CN)
SONG XINBO (CN)
ZHANG LEI (CN)
CHENG YIYU (CN)
WANG YI (CN)
YANG FENGWEN (CN)
ZHENG WENKE (CN)
WANG TAO (CN)
WANG YUEFEI (CN)
ZHANG HAN (CN)
HUANG YUHONG (CN)
WANG PING (CN)
LIU ERWEI (CN)
LIU DAILIN (CN)
ZHANG JINGZE (CN)
HUANG MING (CN)
LIU QINGQUAN (CN)
GAO XIUMEI (CN)
ZHANG JUNHUA (CN)
SONG XINBO (CN)
ZHANG LEI (CN)
CHENG YIYU (CN)
WANG YI (CN)
YANG FENGWEN (CN)
ZHENG WENKE (CN)
WANG TAO (CN)
WANG YUEFEI (CN)
ZHANG HAN (CN)
HUANG YUHONG (CN)
WANG PING (CN)
LIU ERWEI (CN)
LIU DAILIN (CN)
ZHANG JINGZE (CN)
HUANG MING (CN)
Application Number:
PCT/CN2020/112431
Publication Date:
October 14, 2021
Filing Date:
August 31, 2020
Export Citation:
Assignee:
UNIV TIANJIN TRADITIONAL CHINESE MEDICINE (CN)
International Classes:
A61K36/8994; A61K9/16; A61K33/06; A61K47/26; A61P31/14
Foreign References:
| CN108175743A | 2018-06-19 |
Other References:
NATIONAL HEALTH COMMISSION OF THE PEOPLE'S REPUBLIC OF CHINA ET AL.: "Treatment Plan for Covid-19, 6th Edition for Trial Implementation", CHINESE JOURNAL OF INFECTION CONTROL, vol. 19, no. 02, 28 February 2020 (2020-02-28), pages 192 - 195, XP009531020, ISSN: 1671-9638
YANG CHONG , LIANG GUANG-YI , HE ZHU-YING , CAO PEI-XUE , TIAN WEI-YI , CAI LI: "Determination of Glycyrrhizic Acid in Different Decoctions of Sanaotang by HPLC and Comparison with Antifugal Effects in Vitro", CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 32, no. 11, 1 June 2007 (2007-06-01), pages 1031 - 1034, XP055856539
LIN, HUA-XING: "Advances in Chemical Research on the Active Parts of Compound Chinese Medicines and Their Applications", NORTHWEST PHARMACEUTICAL JOURNAL, vol. 24, no. 2, 1 April 2009 (2009-04-01), pages 154 - 156, XP055856542, ISSN: 1004-2407
CUI JING-CHAO,ZHAO ZI-MING: "Progress of Chinese Medicinal Dispensing Granule(Ⅱ)——Survey on Comparative Studies between Single-decoction and Mixed-decoction of Chinese Medicine", CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE, vol. 17, no. 4, 5 January 2011 (2011-01-05), CN, pages 240 - 245, XP055856544, ISSN: 1005-9903, DOI: 10.13422/j.cnki.syfjx.2011.04.071
YANG CHONG , LIANG GUANG-YI , HE ZHU-YING , CAO PEI-XUE , TIAN WEI-YI , CAI LI: "Determination of Glycyrrhizic Acid in Different Decoctions of Sanaotang by HPLC and Comparison with Antifugal Effects in Vitro", CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 32, no. 11, 1 June 2007 (2007-06-01), pages 1031 - 1034, XP055856539
LIN, HUA-XING: "Advances in Chemical Research on the Active Parts of Compound Chinese Medicines and Their Applications", NORTHWEST PHARMACEUTICAL JOURNAL, vol. 24, no. 2, 1 April 2009 (2009-04-01), pages 154 - 156, XP055856542, ISSN: 1004-2407
CUI JING-CHAO,ZHAO ZI-MING: "Progress of Chinese Medicinal Dispensing Granule(Ⅱ)——Survey on Comparative Studies between Single-decoction and Mixed-decoction of Chinese Medicine", CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE, vol. 17, no. 4, 5 January 2011 (2011-01-05), CN, pages 240 - 245, XP055856544, ISSN: 1005-9903, DOI: 10.13422/j.cnki.syfjx.2011.04.071
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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