Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT AND METASTASIS INHIBITION OF COLORECTAL CANCER, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/075122
Kind Code:
A1
Abstract:
The present invention relates to a novel use of AFAP1 antisense RNA1 (AFAP1-AS1) and MLK7 antisense RNA1 (MLK7-AS1) as targets for treatment and metastasis inhibition of colorectal cancer, and, more particularly, to a kit for diagnosing colorectal cancer and a method for diagnosing colorectal cancer, both of which comprise measuring the expression levels of AFAP1-AS1 and MLK7-AS1. In addition, the present invention relates to a pharmaceutical composition for treatment or metastasis inhibition of colorectal cancer, comprising an AFAP1-AS1 inhibitor and an MLK7-AS1 inhibitor.
Inventors:
CHO YONG BEOM (KR)
KIM HYEON HO (KR)
KIM TAE WON (KR)
KIM HYEON HO (KR)
KIM TAE WON (KR)
Application Number:
PCT/KR2022/013191
Publication Date:
May 04, 2023
Filing Date:
September 02, 2022
Export Citation:
Assignee:
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
A61K48/00; A61K31/713; A61K45/06; A61P35/00; A61P35/04; C12Q1/6886
Foreign References:
| US20180305689A1 | 2018-10-25 | |||
| KR20190026819A | 2019-03-13 |
Other References:
POURSHEIKHANI ARASH, ABBASZADEGAN MOHAMMAD REZA, KERACHIAN MOHAMMAD AMIN: "Mechanisms of long non‐coding RNA function in colorectal cancer tumorigenesis", ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 1, 1 February 2021 (2021-02-01), Hoboken, USA, pages 7 - 23, XP093061838, ISSN: 1743-7555, DOI: 10.1111/ajco.13452
ABDUL SATTAR; MAJID ABBASI; WANG JINXIA; LIU QINLONG; SUN MING-ZHONG; LIU SHUQING: "Bidirectional interaction of lncRNA AFAP1-AS1 and CRKL accelerates the proliferative and metastatic abilities of hepatocarcinoma cells", JOURNAL OF ADVANCED RESEARCH, vol. 24, 30 March 2020 (2020-03-30), AMSTERDAM, NL , pages 121 - 130, XP086216426, ISSN: 2090-1232, DOI: 10.1016/j.jare.2020.03.010
KIM, TAE WON ET AL.: "Novel noncoding RNA axis and therapeutic targets for colorectal cancer: AFAP1-AS1 and MLK7-AS1 / miRNA-149-5p and miRNA-485-5p / SHMT2 and IGFBP5", 5TH SAIHST SYMPOSIUM, 20 December 2021 (2021-12-20)
ABDUL SATTAR; MAJID ABBASI; WANG JINXIA; LIU QINLONG; SUN MING-ZHONG; LIU SHUQING: "Bidirectional interaction of lncRNA AFAP1-AS1 and CRKL accelerates the proliferative and metastatic abilities of hepatocarcinoma cells", JOURNAL OF ADVANCED RESEARCH, vol. 24, 30 March 2020 (2020-03-30), AMSTERDAM, NL , pages 121 - 130, XP086216426, ISSN: 2090-1232, DOI: 10.1016/j.jare.2020.03.010
KIM, TAE WON ET AL.: "Novel noncoding RNA axis and therapeutic targets for colorectal cancer: AFAP1-AS1 and MLK7-AS1 / miRNA-149-5p and miRNA-485-5p / SHMT2 and IGFBP5", 5TH SAIHST SYMPOSIUM, 20 December 2021 (2021-12-20)
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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