Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT AND METASTASIS INHIBITION OF COLORECTAL CANCER, COMPRISING MIRNAS, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/075123
Kind Code:
A1
Abstract:
The present invention relates to a novel use of miRNA-149-5p and miRNA-485-5p as targets for treatment and metastasis inhibition of colorectal cancer, and, more particularly, to a colorectal cancer diagnosis kit and a colorectal cancer diagnosis method, both of which comprise measuring the expression levels of miRNA-149-5p and miRNA-485-5p. In addition, the present invention relates to a pharmaceutical composition for treatment or metastasis inhibition of colorectal cancer, comprising miRNA-149-5p and miRNA-485-5p, and a method for screening for therapeutic substances. It has been identified for the first time that if miRNa-149-5p and miRNA-485-5p of the present invention are over-expressed in or used for colorectal cancer cells, the growth and metastasis of colorectal cancer can be effectively inhibited, and thus the biomarkers of the present invention are expected to be widely usable in the fields of colorectal cancer diagnosis, progression prediction, treatment, metastasis inhibition and the like.
Inventors:
CHO YONG BEOM (KR)
KIM HYEON HO (KR)
KIM TAE WON (KR)
KIM HYEON HO (KR)
KIM TAE WON (KR)
Application Number:
PCT/KR2022/013202
Publication Date:
May 04, 2023
Filing Date:
September 02, 2022
Export Citation:
Assignee:
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
A61K48/00; A61K31/7105; A61P35/00; A61P35/04; C12Q1/6886
Foreign References:
| EP2377950B1 | 2014-09-17 |
Other References:
WANG FENG, MA YAN-LEI, ZHANG PENG, SHEN TONG-YI, SHI CHEN-ZHANG, YANG YONG-ZHI, MOYER MARY-PAT, ZHANG HUI-ZHEN, CHEN HONG-QI, LIAN: "SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer : Methylation silencing of miR-149 up-regulates Sp1 and promotes CRC", THE JOURNAL OF PATHOLOGY, vol. 229, no. 1, 1 January 2013 (2013-01-01), Hoboken, USA, pages 12 - 24, XP093062793, ISSN: 0022-3417, DOI: 10.1002/path.4078
PAN YUQIN, SUN HUILING, HU XIUXIU, HE BANGSHUN, LIU XIANGXIANG, XU TAO, CHEN XIAOXIANG, ZENG KAIXUAN, WANG SHUKUI: "The inhibitory role of miR‑485‑5p in colorectal cancer proliferation and invasion via targeting of CD147", ONCOLOGY REPORTS, XP093062795, ISSN: 1021-335X, DOI: 10.3892/or.2018.6309
LIU CHUNQI, WANG LIANG, LIU XIAOCONG, TAN YUPING, TAO LEI, XIAO YUZHOU, DENG PENGCHI, WANG HUIJUAN, DENG QIANYI, LIN YIYUN, JIE HU: "Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation", THERANOSTICS, vol. 11, no. 6, 1 January 2021 (2021-01-01), AU , pages 2966 - 2986, XP093062798, ISSN: 1838-7640, DOI: 10.7150/thno.48699
LIHUI YU, YING LU, XIAOCUI HAN, WENYUE ZHAO, JIAZHI LI, JUN MAO, BO WANG, JIE SHEN, SHUJUN FAN, LU WANG, MEI WANG, LIANHONG LI, JI: "microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5", STEM CELL RESEARCH & THERAPY, vol. 7, no. 1, 1 December 2016 (2016-12-01), XP055529558, DOI: 10.1186/s13287-016-0438-5
PAN, YUQIN ET AL.: "MiR-485-5p as a potential biomarker and tumor suppressor in human colorectal cancer", BIOMARKERS IN MEDICINE, vol. 14, no. 3, 2020, pages 239 - 248, XP009546019
LIU XIAOZHU, YINFENG LI, CUICUI CHEN, LAIQING LI: "miR-149 regulates the proliferation and apoptosis of human colonic carcinoma cells by targeting FZD5", INT J CLIN EXP PATHOL, vol. 13, no. 5, 15 May 2020 (2020-05-15), pages 889 - 895, XP093062863
PAN YUQIN, SUN HUILING, HU XIUXIU, HE BANGSHUN, LIU XIANGXIANG, XU TAO, CHEN XIAOXIANG, ZENG KAIXUAN, WANG SHUKUI: "The inhibitory role of miR‑485‑5p in colorectal cancer proliferation and invasion via targeting of CD147", ONCOLOGY REPORTS, XP093062795, ISSN: 1021-335X, DOI: 10.3892/or.2018.6309
LIU CHUNQI, WANG LIANG, LIU XIAOCONG, TAN YUPING, TAO LEI, XIAO YUZHOU, DENG PENGCHI, WANG HUIJUAN, DENG QIANYI, LIN YIYUN, JIE HU: "Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation", THERANOSTICS, vol. 11, no. 6, 1 January 2021 (2021-01-01), AU , pages 2966 - 2986, XP093062798, ISSN: 1838-7640, DOI: 10.7150/thno.48699
LIHUI YU, YING LU, XIAOCUI HAN, WENYUE ZHAO, JIAZHI LI, JUN MAO, BO WANG, JIE SHEN, SHUJUN FAN, LU WANG, MEI WANG, LIANHONG LI, JI: "microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5", STEM CELL RESEARCH & THERAPY, vol. 7, no. 1, 1 December 2016 (2016-12-01), XP055529558, DOI: 10.1186/s13287-016-0438-5
PAN, YUQIN ET AL.: "MiR-485-5p as a potential biomarker and tumor suppressor in human colorectal cancer", BIOMARKERS IN MEDICINE, vol. 14, no. 3, 2020, pages 239 - 248, XP009546019
LIU XIAOZHU, YINFENG LI, CUICUI CHEN, LAIQING LI: "miR-149 regulates the proliferation and apoptosis of human colonic carcinoma cells by targeting FZD5", INT J CLIN EXP PATHOL, vol. 13, no. 5, 15 May 2020 (2020-05-15), pages 889 - 895, XP093062863
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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