Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCER
Document Type and Number:
WIPO Patent Application WO/2013/125636
Kind Code:
A1
Abstract:
The present invention discloses an antibody that targets a cancer antigen protein expressed specifically on the surface of cancer cells, and the application of the antibody in a treatment and/or preventative agent for said cancer. Specifically disclosed are: an antibody or a fragment thereof, said antibody being immunologically reactive with a partial polypeptide of CAPRIN-1 comprising the amino acid sequence represented by SEQ ID NO: 5 or an amino acid sequence having 80% or more sequence identity to the amino acid sequence represented by SEQ ID NO: 5; and a pharmaceutical composition for the treatment and/or prevention of cancer, said pharmaceutical composition being characterized by containing, as an active ingredient, the antibody or a fragment thereof.
Inventors:
KOBAYASHI SHINICHI (JP)
OKANO FUMIYOSHI (JP)
SAITO TAKANORI (JP)
OKANO FUMIYOSHI (JP)
SAITO TAKANORI (JP)
Application Number:
PCT/JP2013/054337
Publication Date:
August 29, 2013
Filing Date:
February 21, 2013
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07K16/30; A61K39/395; A61P35/00; C12N15/09; C12P21/08
Domestic Patent References:
| WO2010016526A1 | 2010-02-11 | |||
| WO2010016527A1 | 2010-02-11 | |||
| WO2011096535A1 | 2011-08-11 | |||
| WO2011096517A1 | 2011-08-11 | |||
| WO2011096528A1 | 2011-08-11 | |||
| WO2011096533A1 | 2011-08-11 | |||
| WO2011096534A1 | 2011-08-11 | |||
| WO2010016526A1 | 2010-02-11 | |||
| WO2002043478A2 | 2002-06-06 | |||
| WO2002092812A1 | 2002-11-21 | |||
| WO1998046777A1 | 1998-10-22 | |||
| WO1996002576A1 | 1996-02-01 | |||
| WO1999051743A1 | 1999-10-14 | |||
| WO2011096517A1 | 2011-08-11 | |||
| WO2011096528A1 | 2011-08-11 | |||
| WO2011096519A1 | 2011-08-11 | |||
| WO2011096533A1 | 2011-08-11 | |||
| WO2011096534A1 | 2011-08-11 |
Foreign References:
| US5698396A | 1997-12-16 | |||
| JP2012035484A | 2012-02-23 | |||
| JP2007530068A | 2007-11-01 | |||
| EP0239400A2 | 1987-09-30 |
Other References:
BOON ET AL., LUDWIG INSTITUTE FOR CANCER RESEARCH, 1991
TSUYOSHI AKIYOSHI: "Japanese Journal of Cancer and Chemotherapy", vol. 24, 1997, JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY PUBLISHERS INC., pages: 55 - 519
BRUGGEN P. ET AL., SCIENCE, vol. 254, 1991, pages 1643 - 1647
PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 11810 - 11813
INT. J. CANCER, vol. 72, 1997, pages 965 - 971
CANCER RES., vol. 58, 1998, pages 1034 - 1041
INT. J. CANCER, vol. 29, 1998, pages 652 - 658
INT. J. ONCOL., vol. 14, 1999, pages 703 - 708
CANCER RES., vol. 56, 1996, pages 4766 - 4772
HUM. MOL. GENET, vol. 6, 1997, pages 33 - 39
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
"Seikagaku Jikken Koza", 1981, TOKYO KAGAKU DOJIN CO., LTD., article "Protein Chemistry IV, Chemical Modification and Peptide Synthesis"
SAMBROOK ET AL.: "Current Protocols in Molecular Biology", 1989, COLD SPRING HARBOR LABORATORY PRESS, article "Molecular Cloning"
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, article "A compendium of Methods from Current Protocols in Molecular Biology"
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, article "A Compendium of Methods from Current Protocols in Molecular Biology"
SAMBROOK ET AL.: "Current Protocols in Molecular Biology", 1989, article "Molecular Cloning"
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DEST. GROTH, S.F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, I.S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER, G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
CARL; A.K. BORREBAECK; JAMES, W. LARRICK: "THERAPEUTIC MONOCLONAL ANTIBODIES", 1990, MACMILLAN PUBLISHERS LTD
SATO K. ET AL., CANCER RESEARCH, vol. 53, 1993, pages 851 - 856
GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ.; SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER, W.; FRITZ, HJ., METHODS ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA., PROC. NATL. ACAD. SCI. USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTE OF HEALTH
SAMBROOK ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
G.B. KIM ET AL., PROTEIN ENGINEERING DESIGN AND SELECTION, vol. 20, no. 9, 2007, pages 425 - 432
P.J. DELVES: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES", 1997, WILEY
P. SHEPHERD; C. DEAN: "Monoclonal Antibodies.", 2000, OXFORD UNIVERSITY PRESS
J.W. GODING: "Monoclonal Antibodies: principles and practice", 1993, ACADEMIC PRESS
HIDEO SAJI, YAKUGAKU ZASSHI, vol. 128, no. 3, 2008, pages 323 - 332,8
NIWA R., CLINICAL CANCER RESEARCH, vol. 11, no. 6, 15 March 2005 (2005-03-15), pages 2327 - 2336
See also references of EP 2818482A4
TSUYOSHI AKIYOSHI: "Japanese Journal of Cancer and Chemotherapy", vol. 24, 1997, JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY PUBLISHERS INC., pages: 55 - 519
BRUGGEN P. ET AL., SCIENCE, vol. 254, 1991, pages 1643 - 1647
PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 11810 - 11813
INT. J. CANCER, vol. 72, 1997, pages 965 - 971
CANCER RES., vol. 58, 1998, pages 1034 - 1041
INT. J. CANCER, vol. 29, 1998, pages 652 - 658
INT. J. ONCOL., vol. 14, 1999, pages 703 - 708
CANCER RES., vol. 56, 1996, pages 4766 - 4772
HUM. MOL. GENET, vol. 6, 1997, pages 33 - 39
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
"Seikagaku Jikken Koza", 1981, TOKYO KAGAKU DOJIN CO., LTD., article "Protein Chemistry IV, Chemical Modification and Peptide Synthesis"
SAMBROOK ET AL.: "Current Protocols in Molecular Biology", 1989, COLD SPRING HARBOR LABORATORY PRESS, article "Molecular Cloning"
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, article "A compendium of Methods from Current Protocols in Molecular Biology"
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, article "A Compendium of Methods from Current Protocols in Molecular Biology"
SAMBROOK ET AL.: "Current Protocols in Molecular Biology", 1989, article "Molecular Cloning"
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DEST. GROTH, S.F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, I.S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER, G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
CARL; A.K. BORREBAECK; JAMES, W. LARRICK: "THERAPEUTIC MONOCLONAL ANTIBODIES", 1990, MACMILLAN PUBLISHERS LTD
SATO K. ET AL., CANCER RESEARCH, vol. 53, 1993, pages 851 - 856
GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ.; SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER, W.; FRITZ, HJ., METHODS ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA., PROC. NATL. ACAD. SCI. USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTE OF HEALTH
SAMBROOK ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
G.B. KIM ET AL., PROTEIN ENGINEERING DESIGN AND SELECTION, vol. 20, no. 9, 2007, pages 425 - 432
P.J. DELVES: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES", 1997, WILEY
P. SHEPHERD; C. DEAN: "Monoclonal Antibodies.", 2000, OXFORD UNIVERSITY PRESS
J.W. GODING: "Monoclonal Antibodies: principles and practice", 1993, ACADEMIC PRESS
HIDEO SAJI, YAKUGAKU ZASSHI, vol. 128, no. 3, 2008, pages 323 - 332,8
NIWA R., CLINICAL CANCER RESEARCH, vol. 11, no. 6, 15 March 2005 (2005-03-15), pages 2327 - 2336
See also references of EP 2818482A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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