Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/257438
Kind Code:
A1
Abstract:
A pharmaceutical composition for inhibiting N-nitrosodimethylamine (NDMA) formation, and a method. In a pharmaceutical composition containing a selection of metformin, valsartan, irbesartan, losartan, sumatriptan, diltiazem, tetracycline, doxylamine, chlorphenamine, fluvoxamine, and/or any salt thereof, a non-antioxidant acidic component is added, causing N-nitrosodimethylamine content within an effective period of the pharmaceutical to be suppressed to lower than an acceptable daily intake limit therefor.
Inventors:
GONG JIAN (CN)
LIU MANMAN (CN)
HU CHENGSONG (CN)
CHEN YISHENG (CN)
ZHANG GUOHUA (CN)
LIU MANMAN (CN)
HU CHENGSONG (CN)
CHEN YISHENG (CN)
ZHANG GUOHUA (CN)
Application Number:
PCT/CN2021/143011
Publication Date:
December 15, 2022
Filing Date:
December 30, 2021
Export Citation:
Assignee:
NOVAST LABORATORIES LTD (CN)
International Classes:
A61K33/00; A61K9/00; A61K45/00; A61K47/10; A61K47/12; A61K47/20; A61K47/34; A61K47/42; A61K47/46
Foreign References:
| US20090053310A1 | 2009-02-26 | |||
| US20150196509A1 | 2015-07-16 | |||
| CN101987081A | 2011-03-23 | |||
| GB1186482A | 1970-04-02 |
Other References:
HU JINGLI, CHRISTISON TERRI, ROHRER JEFFREY: "Determination of dimethylamine and nitrite in pharmaceuticals by ion chromatography to assess the likelihood of nitrosamine formation", HELIYON, ELSEVIER LTD, GB, vol. 7, no. 2, 1 February 2021 (2021-02-01), GB , pages e06179, XP093013277, ISSN: 2405-8440, DOI: 10.1016/j.heliyon.2021.e06179
WEI YANLING, TANG JING;WANG JIAN;WANG YONGLI;ZHANG JIANHAO: "Inhibitory Effect of Ferulic Acid as on Biogenic Amines and N-Nitrosamine in Dry-Cured Perch", FOOD SCIENCE, BEIJING FOOD SCIENCE RESEARCH INSTITUTE, CN, vol. 36, no. 8, 31 December 2015 (2015-12-31), CN , pages 266 - 273, XP093013278, ISSN: 1002-6630, DOI: 10.7506/spkx1002-6630-201508050
LI LING, XIA TIAN-LAN, XU XING-LIAN, ZHOU GUANG-HONG: "Research Progress in Inhibition of N-Nitrosamine Formation in Meat Products and Gastric Acid System", FOOD SCIENCE, BEIJING FOOD SCIENCE RESEARCH INSTITUTE, CN, vol. 34, no. 5, 15 March 2013 (2013-03-15), CN , pages 284 - 288, XP093013280, ISSN: 1002-6630
WEI YANLING, TANG JING;WANG JIAN;WANG YONGLI;ZHANG JIANHAO: "Inhibitory Effect of Ferulic Acid as on Biogenic Amines and N-Nitrosamine in Dry-Cured Perch", FOOD SCIENCE, BEIJING FOOD SCIENCE RESEARCH INSTITUTE, CN, vol. 36, no. 8, 31 December 2015 (2015-12-31), CN , pages 266 - 273, XP093013278, ISSN: 1002-6630, DOI: 10.7506/spkx1002-6630-201508050
LI LING, XIA TIAN-LAN, XU XING-LIAN, ZHOU GUANG-HONG: "Research Progress in Inhibition of N-Nitrosamine Formation in Meat Products and Gastric Acid System", FOOD SCIENCE, BEIJING FOOD SCIENCE RESEARCH INSTITUTE, CN, vol. 34, no. 5, 15 March 2013 (2013-03-15), CN , pages 284 - 288, XP093013280, ISSN: 1002-6630
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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