Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/257439
Kind Code:
A1
Abstract:
A pharmaceutical composition and method for inhibiting formation of N-nitrosodimethylamine (NDMA). Within the expiration date of a pharmaceutical composition comprising one selected from metformin, valsartan, irbesartan, losartan, sumatriptan, diltiazem, tetracycline, doxylamine, chlorpheniramine, carbinamine, and/or any salt thereof, the content of NDMA is kept below an acceptable daily intake limit.
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Inventors:
GONG JIAN (CN)
LIU MANMAN (CN)
HU CHENGSONG (CN)
CHEN YISHENG (CN)
ZHANG GUOHUA (CN)
LIU MANMAN (CN)
HU CHENGSONG (CN)
CHEN YISHENG (CN)
ZHANG GUOHUA (CN)
Application Number:
PCT/CN2021/143012
Publication Date:
December 15, 2022
Filing Date:
December 30, 2021
Export Citation:
Assignee:
NOVAST LABORATORIES LTD (CN)
International Classes:
A61K31/155; A61K9/51; A61K33/00; A61K45/00; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/22; A61K47/34; A61K47/42; A61K47/46; A61P3/10; A61P35/00
Foreign References:
| US20130224296A1 | 2013-08-29 | |||
| CN113117084A | 2021-07-16 | |||
| US20080033027A1 | 2008-02-07 | |||
| US20140107170A1 | 2014-04-17 |
Other References:
HU JINGLI, CHRISTISON TERRI, ROHRER JEFFREY: "Determination of dimethylamine and nitrite in pharmaceuticals by ion chromatography to assess the likelihood of nitrosamine formation", HELIYON, ELSEVIER LTD, GB, vol. 7, no. 2, 1 February 2021 (2021-02-01), GB , pages e06179, XP093013277, ISSN: 2405-8440, DOI: 10.1016/j.heliyon.2021.e06179
XING BILIANG: "Studies on the Formation and Control of Volatile N-Nitrosamines in Dry-Cured Meat ", CHINA DOCTORAL DISSERTATIONS/MASTER'S THESES FULL-TEXT DATABASE, ENGINEERING SCIENCE AND TECHNOLOGY I, no. 6, 15 June 2012 (2012-06-15), XP093014227
WEI FASHAN, XU XINGLIAN, ZHOU GUANGHONG: "Review on Studies of N-nitroso Compound in Cured Meat", ROULEI YANJIU - MEAT RESEARCH, ZHONGGUO ROULEI SHIPIN ZONGHE YANJIU ZHONGXIN, BEIJING, CN, no. 3, 15 March 2008 (2008-03-15), CN , pages 8 - 12, XP093014219, ISSN: 1001-8123
HUANG ZONGHAI, MENG PEI-PEI, SUN WEI-QING, ZHU YING-CHUN, YANG HUA, WANG RUI, MA LI-ZHEN: "Effect of Hydroxyl Radical Oxidizing Systems on Formation of Ndma on The Simulated System", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, GAI KAN BIANJIBU , BEIJING, CN, no. 9, 1 May 2013 (2013-05-01), CN , pages 62 - 66, XP093014213, ISSN: 1002-0306, DOI: 10.13386/j.issn1002-0306.2013.09.037
XING BILIANG: "Studies on the Formation and Control of Volatile N-Nitrosamines in Dry-Cured Meat ", CHINA DOCTORAL DISSERTATIONS/MASTER'S THESES FULL-TEXT DATABASE, ENGINEERING SCIENCE AND TECHNOLOGY I, no. 6, 15 June 2012 (2012-06-15), XP093014227
WEI FASHAN, XU XINGLIAN, ZHOU GUANGHONG: "Review on Studies of N-nitroso Compound in Cured Meat", ROULEI YANJIU - MEAT RESEARCH, ZHONGGUO ROULEI SHIPIN ZONGHE YANJIU ZHONGXIN, BEIJING, CN, no. 3, 15 March 2008 (2008-03-15), CN , pages 8 - 12, XP093014219, ISSN: 1001-8123
HUANG ZONGHAI, MENG PEI-PEI, SUN WEI-QING, ZHU YING-CHUN, YANG HUA, WANG RUI, MA LI-ZHEN: "Effect of Hydroxyl Radical Oxidizing Systems on Formation of Ndma on The Simulated System", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, GAI KAN BIANJIBU , BEIJING, CN, no. 9, 1 May 2013 (2013-05-01), CN , pages 62 - 66, XP093014213, ISSN: 1002-0306, DOI: 10.13386/j.issn1002-0306.2013.09.037
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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