Title:
PHARMACEUTICAL COMPOSITIONS COMPRISING THIRAM FOR INHIBITING ANGIOGENESIS
Document Type and Number:
WIPO Patent Application WO1999034763
Kind Code:
A3
Abstract:
Thiram (tetramethylthiuram disulfide) is shown to inhibit angiogenesis and/or inflammation and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and in the inhibition, treatment and alleviation of inflammation associated with several disorders and diseases, such as rheumatoid arthritis. Thiram is further useful for prevention of cell hyperproliferation and formation of clots along or around medical devices.
Inventors:
MARIKOVSKY MOSHE (IL)
Application Number:
PCT/IL1999/000018
Publication Date:
August 24, 2000
Filing Date:
January 11, 1999
Export Citation:
Assignee:
YEDA RES & DEV (IL)
MARIKOVSKY MOSHE (IL)
MARIKOVSKY MOSHE (IL)
International Classes:
A61K31/27; A61L33/00; A61P9/10; A61P13/12; A61P17/00; A61P19/04; A61P19/08; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P37/06; A61P37/08; A61P43/00; (IPC1-7): A61K31/27
Domestic Patent References:
| WO1995030415A1 | 1995-11-16 |
Foreign References:
| EP0284879A2 | 1988-10-05 |
Other References:
M. TAKAHASHI: "Inhibition of spontaneous leukemia in F-344 rats by tetramethylthiuram disulfide", GANN, vol. 74, no. 6, 1983, pages 810 - 813, XP002108882
G. WEBER: "Neue systemische Therapie der Psoriasis", HAUTARZT, vol. 36, no. 1, 1985, pages 20 - 24, XP002108883
B.S. WARREN: "Mechanisms of inhibition of tumor progression", BASIC LIFE SCI., vol. 61, 1993, pages 279 - 289, XP002108884
G.Y. LIU: "Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through cordinative modulation of NFkB, c-fos/c-jun, and p53 proteins", MOL. CARCINOGEN., vol. 22, no. 4, 1988, pages 235 - 246, XP002108885
D.J. STEWART: "Phase I study of the combination of disulfiram with cisplatin", AM. J. CLIN. ONCOL., vol. 10, no. 6, 1987, pages 517 - 519, XP002108886
H.K.A. SCHIRMER: "Disulfiram and tumor inhibition", TRANSACTIONS OF THE AMERICAN ASSOCIATION OF GENITO-URINARY SURGEONS, vol. 58, 1966, pages 63 - 66, XP002108887
G.N. HANNAN: "Regulation of polypeptide synthesis in endothelial cells and hybridoma cells by the copper ionophore disulfiram", CELL. BIOL. INT. REP., vol. 6, no. 5, 1982, pages 423 - 432, XP002108888
G. WEBER: "Neue systemische Therapie der Psoriasis", HAUTARZT, vol. 36, no. 1, 1985, pages 20 - 24, XP002108883
B.S. WARREN: "Mechanisms of inhibition of tumor progression", BASIC LIFE SCI., vol. 61, 1993, pages 279 - 289, XP002108884
G.Y. LIU: "Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through cordinative modulation of NFkB, c-fos/c-jun, and p53 proteins", MOL. CARCINOGEN., vol. 22, no. 4, 1988, pages 235 - 246, XP002108885
D.J. STEWART: "Phase I study of the combination of disulfiram with cisplatin", AM. J. CLIN. ONCOL., vol. 10, no. 6, 1987, pages 517 - 519, XP002108886
H.K.A. SCHIRMER: "Disulfiram and tumor inhibition", TRANSACTIONS OF THE AMERICAN ASSOCIATION OF GENITO-URINARY SURGEONS, vol. 58, 1966, pages 63 - 66, XP002108887
G.N. HANNAN: "Regulation of polypeptide synthesis in endothelial cells and hybridoma cells by the copper ionophore disulfiram", CELL. BIOL. INT. REP., vol. 6, no. 5, 1982, pages 423 - 432, XP002108888
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