Title:
PHARMACEUTICAL COMPOSITIONS OF GALLIUM COMPLEXES OF 3-HYDROXY-4-PYRONES
Document Type and Number:
WIPO Patent Application WO/1993/009776
Kind Code:
A1
Abstract:
Disclosed are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. These compositions provide enhanced gallium bioavailability particularly when orally administered as compared to the gallium bioavailability achieved by use of pharmaceutical compositions containing gallium salts. Compositions included in this invention are useful in providing gallium to humans and other mammals for a wide variety of medical and veterinary applications, including the treatment, prevention, or diagnosis of hypercalcemia, certain cancers, certain disorders of calcium homeostasis, and certain bone diseases including osteoporosis, osteopenia, and Paget's disease.
Inventors:
BERNSTEIN LAWRENCE RICHARD (US)
Application Number:
PCT/US1991/008239
Publication Date:
May 27, 1993
Filing Date:
November 12, 1991
Export Citation:
Assignee:
BERNSTEIN LAWRENCE RICHARD (US)
International Classes:
A61K31/28; A61K31/351; A61K31/35; A61K31/555; A61K33/24; A61P3/02; A61P3/14; A61P7/00; A61P19/08; A61P19/10; A61P35/00; A61P43/00; C07D309/40; C07F5/00; (IPC1-7): A61K31/35; C07F5/00
Domestic Patent References:
| WO1991017751A1 | 1991-11-28 |
Foreign References:
| GB2242191B | 1993-12-08 | |||
| US4665064A | 1987-05-12 |
Other References:
FARRAR, G. et al., Food and Chem. Toxic, Vol. 26, No. 6, 1988, "Tissue Distribution of Gallium Following Administration of the Gallium-Maltol Complex in the Rat: A Model for an Aluminum Maltol Complex of Neurotoxicological intrest", p. 523-5, see entire document.
FINNEGAN, M. et al., Inorg. Chem., Vol. 26, No. 13, 1987, "Neutral Water Soluble Post Transition Metal Chelate Complex es ot Medical Interest: Aluminum and Gallium Tris (3 Hydrox 4 Pyronates)", p. 2171-6, see entire document.
DeVITA, Jr. (ED) "Important Advances in Oncology 1989", published by J.P. Lippincott Company, Philadelphia, PA, see entire document.
FINNEGAN, M. et al., Inorg. Chem., Vol. 26, No. 13, 1987, "Neutral Water Soluble Post Transition Metal Chelate Complex es ot Medical Interest: Aluminum and Gallium Tris (3 Hydrox 4 Pyronates)", p. 2171-6, see entire document.
DeVITA, Jr. (ED) "Important Advances in Oncology 1989", published by J.P. Lippincott Company, Philadelphia, PA, see entire document.
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