Title:
TOCOTRIENOLS AND TOCOTRIENOL-LIKE COMPOUNDS AND METHODS FOR THEIR USE
Document Type and Number:
WIPO Patent Application WO/1993/009777
Kind Code:
A1
Abstract:
The present invention relates to novel tocotrienols and tocotrienol-like compounds displaying biological activity. The tocotrienols and tocotrienol-like compounds of this invention may be conveniently obtained from biological sources or by chemical synthesis and may be used in pharmaceutical compositions, foodstuffs and dietary supplements. This invention also relates to the use of tocotrienols, tocotrienol-like compounds, and mixtures thereof, as hypocholesterolemic, antithrombotic, antioxidizing, antiatherogenic, antiinflammatory and immunoregulatory agents, or as agents useful to decrease lipoprotein (a) concentration in the blood or to increase feed conversion efficiency.
Inventors:
LANE RONALD H (US)
QURESHI ASAF A (US)
SALSER WINSTON A (US)
QURESHI ASAF A (US)
SALSER WINSTON A (US)
Application Number:
PCT/US1992/010277
Publication Date:
May 27, 1993
Filing Date:
November 20, 1992
Export Citation:
Assignee:
LIPOGENICS INC (US)
International Classes:
A23K1/14; A23K1/16; A23L1/30; A23L33/15; C12N9/99; A61K31/05; A61K31/12; A61K31/135; A61K31/19; A61K31/215; A61K31/22; A61K31/35; A61K31/352; A61K31/353; A61K31/355; A61K31/365; A61K31/455; A61K31/47; A61P3/06; A61P3/08; A61P3/10; A61P7/02; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C33/38; C07C39/23; C07C43/23; C07C63/66; C07C211/28; C07C211/60; C07C229/40; C07D215/20; C07D311/58; C07D311/64; C07D311/70; C07D311/72; C07D313/00; C07D313/08; C07D313/20; C07D333/56; C07D333/58; C07D333/60; C07D333/62; C07D335/06; C07D337/08; C07D337/16; C11B1/02; C11B1/10; C11B3/00; (IPC1-7): A61K31/355; C07C39/23; C07D311/22; C07D311/72
Foreign References:
| EP0421419A2 | 1991-04-10 | |||
| EP0304842A2 | 1989-03-01 | |||
| GB1011319A | 1965-11-24 | |||
| DE3221506A1 | 1983-12-08 | |||
| GB870638A | 1961-06-14 | |||
| US3064012A | 1962-11-13 | |||
| US3026330A | 1962-03-20 | |||
| GB1506076A | 1978-04-05 |
Other References:
HELVETICA CHIMICA ACTA, vol. 46, no. 7, 2 December 1963, Basel, CH, pages 2517 - 2526 P. SCHUDEL, ET AL.: ']ber Synthese von rac. all-trans-zeta 1- und -epsilon Tocopherol'
PATENT ABSTRACTS OF JAPAN vol. 9, no. 91 (C-277)(1814) 19 April 1985
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 261, no. 23, 15 August 1986, Baltimore, US, pages 10544 - 10550 A.A. QURESHI, ET AL.: 'The structure of an inhibitor of cholesterol biosynthesis isolated from barley' cited in the application
PATENT ABSTRACTS OF JAPAN vol. 9, no. 91 (C-277)(1814) 19 April 1985
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 261, no. 23, 15 August 1986, Baltimore, US, pages 10544 - 10550 A.A. QURESHI, ET AL.: 'The structure of an inhibitor of cholesterol biosynthesis isolated from barley' cited in the application
Download PDF: