Title:
PHARMACEUTICAL PREPARATION TO BE ADMINISTERED INTO RESPIRATORY ORGANS FOR TREATING OR PREVENTING INFLAMMATORY RESPIRATORY DISEASES, AND METHOD FOR TREATING OR PREVENTING SUCH DISEASES
Document Type and Number:
WIPO Patent Application WO/2010/131909
Kind Code:
A3
Abstract:
The present invention relates to a pharmaceutical preparation to be administered into respiratory organs for treating or preventing inflammatory respiratory diseases, comprising a peptide which acts on formyl peptide receptors (FPRs) or receptors analogous thereto, in an amount which is effective in suppressing respiratory inflammation. The present invention also relates to a method for treating or preventing inflammatory respiratory diseases by using the preparation, and to a kit containing the preparation. As compared with systemic administration of the peptide by injection, direct administration of the peptide to respiratory organs remarkedly improves the effect in suppressing respiratory inflammation.
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Inventors:
KIM YOON KEUN (KR)
GHO YONG SONG (KR)
TAE YOU ME (KR)
BAE YOE SIK (KR)
RYU SUNG HO (KR)
GHO YONG SONG (KR)
TAE YOU ME (KR)
BAE YOE SIK (KR)
RYU SUNG HO (KR)
Application Number:
PCT/KR2010/003015
Publication Date:
March 17, 2011
Filing Date:
May 12, 2010
Export Citation:
Assignee:
POSTECH ACAD IND FOUND (KR)
KIM YOON KEUN (KR)
GHO YONG SONG (KR)
TAE YOU ME (KR)
BAE YOE SIK (KR)
RYU SUNG HO (KR)
KIM YOON KEUN (KR)
GHO YONG SONG (KR)
TAE YOU ME (KR)
BAE YOE SIK (KR)
RYU SUNG HO (KR)
International Classes:
A61K38/08; A61K9/12; A61P11/00; A61P29/00
Domestic Patent References:
| WO2005077412A2 | 2005-08-25 |
Other References:
KANG, H.K. ET AL.: "The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2.", J. IMMUNOL., vol. 175, no. 2, 15 July 2005 (2005-07-15), pages 685 - 692, XP008161782
ATZORI. L. ET AL.: "Absence of proteinase-activated receptor- signaling in mice confers protection from fMLP-induced goblet cell metaplasia.", AM. J. RESPIR. CELL MOL. BIOL., vol. 41, no. 6, 23 March 2009 (2009-03-23), pages 680 - 687, XP008161805
LI, B. Q. ET AL.: "The synthetic peptide WKYMVm at tenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1.", BLOOD., vol. 97, no. 10, 15 May 2001 (2001-05-15), pages 2941 - 2947, XP002972742
BAE, Y. S. ET AL.: "Differential activation of formyl peptide receptor signaling by peptide ligands.", MOL. PHARMACOL., vol. 64, no. 4, October 2003 (2003-10-01), pages 841 - 847, XP002539952
MATHESON, M. ET AL.: "Cigarette smoking increases neutrophil formyl methionyl leucyl phenylalanine receptor numbers.", CHEST., vol. 123, no. 5, May 2003 (2003-05-01), pages 1642 - 1646, XP008161783
ATZORI. L. ET AL.: "Absence of proteinase-activated receptor- signaling in mice confers protection from fMLP-induced goblet cell metaplasia.", AM. J. RESPIR. CELL MOL. BIOL., vol. 41, no. 6, 23 March 2009 (2009-03-23), pages 680 - 687, XP008161805
LI, B. Q. ET AL.: "The synthetic peptide WKYMVm at tenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1.", BLOOD., vol. 97, no. 10, 15 May 2001 (2001-05-15), pages 2941 - 2947, XP002972742
BAE, Y. S. ET AL.: "Differential activation of formyl peptide receptor signaling by peptide ligands.", MOL. PHARMACOL., vol. 64, no. 4, October 2003 (2003-10-01), pages 841 - 847, XP002539952
MATHESON, M. ET AL.: "Cigarette smoking increases neutrophil formyl methionyl leucyl phenylalanine receptor numbers.", CHEST., vol. 123, no. 5, May 2003 (2003-05-01), pages 1642 - 1646, XP008161783
Attorney, Agent or Firm:
LEE, Myoung-Jin (Wooil Building725-32 Yeoksam-dong,Gangnam-gu, Seoul 135-921, KR)
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