Title:
PHENETHYLAMINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/009053
Kind Code:
A1
Abstract:
Compounds represented by general formula (1) which are phenethylamine derivatives exhibiting a motilin receptor antagonism etc. and being useful as drugs, wherein A represents an amino acid residue, etc.; R¿1? represents R¿6?-CO-, etc.; R¿2? represents hydrogen, etc.; R¿3? represents -CO-R¿7?, etc.; R¿4? represents alkyl, etc.; R¿5? represents hydroxy, etc.; R¿6? represents alkyl, etc.; and R¿7? represents amino, etc.
Inventors:
KOTAKE KEN-ICHIRO (JP)
KOZONO TOSHIRO (JP)
SATO TSUTOMU (JP)
TAKANASHI HISANORI (JP)
KOZONO TOSHIRO (JP)
SATO TSUTOMU (JP)
TAKANASHI HISANORI (JP)
Application Number:
PCT/JP1998/003627
Publication Date:
February 25, 1999
Filing Date:
August 14, 1998
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
KOTAKE KEN ICHIRO (JP)
KOZONO TOSHIRO (JP)
SATO TSUTOMU (JP)
TAKANASHI HISANORI (JP)
KOTAKE KEN ICHIRO (JP)
KOZONO TOSHIRO (JP)
SATO TSUTOMU (JP)
TAKANASHI HISANORI (JP)
International Classes:
C07K5/02; C07K5/06; C07K5/065; C07K5/08; C07K5/087; C07K5/09; C07K5/093; C07K5/097; A61K38/00; (IPC1-7): C07K5/08; C07K5/06; A61K38/06; A61K38/05
Domestic Patent References:
| WO1996040208A1 | 1996-12-19 | |||
| WO1994003483A1 | 1994-02-17 |
Other References:
DEPOORTERE I., ET AL.: "ANTAGONISTIC PROPERTIES OF ÚPHE3,LEU13¾PORCINE MOTILIN.", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 286., 1 January 1995 (1995-01-01), NL, pages 241 - 247., XP002913859, ISSN: 0014-2999, DOI: 10.1016/0014-2999(95)00453-5
POITRAS, P., ET AL.: "MOTILIN SYNTHETIC ANALOGUES AND MOTILIN RECEPTOR ANTAGONISTS.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 205., no. 01., 1 January 1994 (1994-01-01), US, pages 449 - 454., XP002913858, ISSN: 0006-291X, DOI: 10.1006/bbrc.1994.2686
TAKANASHI H., ET AL.: "GM-109: A NOVEL, SELECTIVE MOTILIN RECEPTOR ANTAGONIST IN THE SMOOTH MUSCLE OF THE RABBIT SMALL INTESTINE.", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 273., no. 02., 1 January 1995 (1995-01-01), US, pages 624 - 628., XP002913857, ISSN: 0022-3565
POITRAS, P., ET AL.: "MOTILIN SYNTHETIC ANALOGUES AND MOTILIN RECEPTOR ANTAGONISTS.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 205., no. 01., 1 January 1994 (1994-01-01), US, pages 449 - 454., XP002913858, ISSN: 0006-291X, DOI: 10.1006/bbrc.1994.2686
TAKANASHI H., ET AL.: "GM-109: A NOVEL, SELECTIVE MOTILIN RECEPTOR ANTAGONIST IN THE SMOOTH MUSCLE OF THE RABBIT SMALL INTESTINE.", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 273., no. 02., 1 January 1995 (1995-01-01), US, pages 624 - 628., XP002913857, ISSN: 0022-3565
Attorney, Agent or Firm:
Shamoto, Ichio (New Ohtemachi Building 2-1, Ohtemachi 2-chome Chiyoda-ku Tokyo, JP)
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