Title:
PHENYL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/047701
Kind Code:
A1
Abstract:
A compound represented by general formula (I-1) (where all of the symbols are as defined in the specification) has a powerful human S1P2 antagonist action as a result of the introduction of two cyclic groups, particularly phenoxy groups, at predetermined substitution positions of said compound. It is therefore possible to obtain a therapeutic agent for S1P2-mediated disease, such as vasoconstriction-related disease, fibrosis, respiratory disease, and the like.
Inventors:
NAGANAWA ATSUSHI (JP)
KUSUMI KENSUKE (JP)
OTSUKI KAZUHIRO (JP)
SEKIGUCHI TETSUYA (JP)
KAKUUCHI AKITO (JP)
SHINOZAKI KOJI (JP)
YAMAMOTO HIROSHI (JP)
NONAKA SHIGEYUKI (JP)
KUSUMI KENSUKE (JP)
OTSUKI KAZUHIRO (JP)
SEKIGUCHI TETSUYA (JP)
KAKUUCHI AKITO (JP)
SHINOZAKI KOJI (JP)
YAMAMOTO HIROSHI (JP)
NONAKA SHIGEYUKI (JP)
Application Number:
PCT/JP2012/074968
Publication Date:
April 04, 2013
Filing Date:
September 27, 2012
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07D205/04; A61K31/397; A61K31/40; A61K31/445; A61K31/4523; A61K31/453; A61K31/454; A61K31/4545; A61K31/5377; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P25/00; A61P43/00; C07D207/10; C07D207/12; C07D211/48; C07D401/12; C07D405/12
Domestic Patent References:
| WO2011082285A1 | 2011-07-07 | |||
| WO2001098301A1 | 2001-12-27 | |||
| WO2004002531A1 | 2004-01-08 | |||
| WO2005063704A1 | 2005-07-14 |
Foreign References:
| JP2011524881A | 2011-09-08 | |||
| JP2010514693A | 2010-05-06 | |||
| JP2009534440A | 2009-09-24 | |||
| CN1590378A | 2005-03-09 |
Other References:
See also references of EP 2762466A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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Claims: