Title:
PHENYLTRIAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/100054
Kind Code:
A1
Abstract:
Provided is a novel compound useful for the prevention or treatment of diseases such as dementia, Alzheimer's disease, attention deficit hyperactivity disorder, schizophrenia, epilepsy, central convulsions, obesity, diabetes, hyperlipemia, narcolepsy, idiopathic hypersomnia, behaviorally induced insufficient sleep syndrome, sleep apnea syndrome, circadian rhythm disorder, parasomnia, sleep related movement disorders, insomnia, depression or allergic rhinitis, or a pharmaceutically acceptable salt thereof. Specifically provided is a phenyltriazole derivative represented by formula (I) or a pharmaceutically acceptable salt thereof. Formula (I) [wherein, the ring P represents a group represented by formula (II) or (III); and Q represents a group represented by formula (A) or (B).]
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Inventors:
NAKAMURA TOSHIO (JP)
MASUDA SEIJI (JP)
MASUDA SEIJI (JP)
Application Number:
PCT/JP2012/083882
Publication Date:
July 04, 2013
Filing Date:
December 27, 2012
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D401/12; A61K31/4192; A61K31/454; A61P3/04; A61P3/06; A61P3/10; A61P11/00; A61P11/02; A61P25/08; A61P25/14; A61P25/18; A61P25/20; A61P25/24; A61P25/26; A61P25/28; A61P37/08; A61P43/00; C07D401/14; C07D403/12; C07D403/14
Domestic Patent References:
| WO2002012190A2 | 2002-02-14 | |||
| WO2006117609A2 | 2006-11-09 | |||
| WO2007075629A2 | 2007-07-05 | |||
| WO2008072724A1 | 2008-06-19 | |||
| WO2009063953A1 | 2009-05-22 | |||
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HANCOCK A.A. ET AL., CURR. OPIN. INVESTIG. DRUG, vol. 4, pages 1190 - 1197
HUANG Z-L. ET AL., PROG. NATR. ACAD. SCI., vol. 103, 2006, pages 4687 - 4692
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PASSANI M.B. ET AL., TRENDS IN PHARMACOL. SCI., vol. 25, 2004, pages 618 - 625
LEURS R. ET AL., NATURE DRUG DISCOVERY, vol. 4, 2005, pages 107 - 122
LEURS R. ET AL., DRUG DISCOVERY TODAY, vol. 10, 2005, pages 1613 - 1627
LIANG ET AL., SYNLETT, vol. 14, 2005, pages 2209 - 2213
SYNTHESIS, 2011, pages 223 - 228
T. W. GREENE; P. G. M. WUTS: "Protective Groups in Organic Synthesis", JOHN WILEY AND SONS
JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 6889
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 66, 1944, pages 1442
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See also references of EP 2799436A4
PESCHKE BERND ET AL.: "Cinnamic amides of (S)-2-(aminomethyl)pyrrolidines are potent H3 antagonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, 2004, pages 2603 - 2616, XP002355169
LOVENBERG T.W. ET AL., MOLECULAR PHARMACOLOGY, vol. 55, 1999, pages 1101 - 1107
ARRANG J-M. ET AL., NATURE, vol. 302, 1983, pages 832 - 837
BROWN R.E. ET AL., PROGRESS IN NEUROBIOLOGY, vol. 63, 2001, pages 637 - 672
HUANG Y-W. ET AL., BEHAVIOURAL BRAIN RESEARCH, vol. 151, 2004, pages 287 - 293
KOMATER V.A. ET AL., BEHAVIOURAL BRAIN RESEARCH, vol. 159, 2005, pages 295 - 300
PASSANI M.B. ET AL., NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, vol. 24, 2000, pages 107 - 113
FOX G.B. ET AL., J. PHARMACOL. EXP. THER., vol. 313, 2005, pages 176 - 190
HANCOCK A.A. ET AL., CURR. OPIN. INVESTIG. DRUG, vol. 4, pages 1190 - 1197
HUANG Z-L. ET AL., PROG. NATR. ACAD. SCI., vol. 103, 2006, pages 4687 - 4692
BABIER A.J. ET AL., BR. J. PHARMACOL., vol. 143, 2004, pages 649 - 661
MCLEOD R.L. ET AL., AM. J. RHINOL., vol. 13, 1999, pages 391 - 399
SCHWARTZ J.C. ET AL., TRENDS IN PHARMACOL. SCI., vol. 7, 1986, pages 24 - 28
PASSANI M.B. ET AL., TRENDS IN PHARMACOL. SCI., vol. 25, 2004, pages 618 - 625
LEURS R. ET AL., NATURE DRUG DISCOVERY, vol. 4, 2005, pages 107 - 122
LEURS R. ET AL., DRUG DISCOVERY TODAY, vol. 10, 2005, pages 1613 - 1627
LIANG ET AL., SYNLETT, vol. 14, 2005, pages 2209 - 2213
SYNTHESIS, 2011, pages 223 - 228
T. W. GREENE; P. G. M. WUTS: "Protective Groups in Organic Synthesis", JOHN WILEY AND SONS
JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 6889
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 66, 1944, pages 1442
JOURNAL OF ORGANIC CHEMISTRY, vol. 70, 2005, pages 1050
See also references of EP 2799436A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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