PHOSPHORYLATED SARM1, ANTIBODY, SARM1 PHOSPHORYLATION INHIBITOR, PROPHYLACTIC OR THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASES, SCREENING METHOD, MODIFIED SARM1, AND USE

WIPO Patent Application WO/2017/164230

A1

The present invention provides a phosphorylated SARM1 (Sterile alpha and TIR motif-containing protein 1) in which at least one Ser residue selected from the group consisting of position 54, position 548, and position 622 of SARM1 is phosphorylated.

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MURATA HITOSHI (JP)
SAKAGUCHI MASAKIYO (JP)
KINOSHITA RIE (JP)
YAMAMOTO KENICHI (JP)

PCT/JP2017/011418

September 28, 2017

March 22, 2017

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NAT UNIV CORP OKAYAMA UNIV (JP)

A01K67/027; C07K14/47; A61K38/02; A61K39/395; A61K45/00; A61P25/00; A61P25/16; A61P25/28; C07K16/18; C12N5/10; G01N33/15; G01N33/50; C12N15/09

JP2015506376A	2015-03-02
US20120328629A1	2012-12-27

MUKHERJEE P. ET AL.: "Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.", IMMUNITY, vol. 38, no. 4, 2013, pages 705 - 716, XP055602037
GERDTS J. ET AL.: "Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.", NEURON, vol. 89, no. 3, 2016, pages 449 - 460, XP029406975, DOI: doi:10.1016/j.neuron.2015.12.023

SAEGUSA & PARTNERS (JP)

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