Title:
PHOTOCLEAVABLE CYCLIC OLIGONUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/1997/047639
Kind Code:
A1
Abstract:
A photocleavable cyclic oligonucleotide having a base sequence capable of hybridizing with a target DNA or RNA and a structure cyclized with a photocleavable linkage. The oligonucleotide is not decomposed by nucleases in the living body owing to its cyclic structure, so that it can be diffused to predetermined positions in the body by taking a sufficiently prolonged time. Further, the linkage is cleaved by irradiation with a suitable light after the lapse of a predetermined time, by which the cyclic oligonucleotide is converted into a linear one, thus acting as an antisense oligonucleotide.
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Inventors:
SHIONO HIROFUMI (JP)
KODAMA HIROFUMI (JP)
KOJIMA MAKIKO (JP)
KODAMA HIROFUMI (JP)
KOJIMA MAKIKO (JP)
Application Number:
PCT/JP1997/001959
Publication Date:
December 18, 1997
Filing Date:
June 09, 1997
Export Citation:
Assignee:
LAB MOLECULAR BIOPHOTONICS (JP)
SHIONO HIROFUMI (JP)
KODAMA HIROFUMI (JP)
KOJIMA MAKIKO (JP)
SHIONO HIROFUMI (JP)
KODAMA HIROFUMI (JP)
KOJIMA MAKIKO (JP)
International Classes:
C07H21/00; (IPC1-7): C07H21/02; C07H21/04; C12N15/00
Foreign References:
| FR2675803A1 | 1992-10-30 | |||
| JPH0856679A | 1996-03-05 |
Other References:
J. AM. CHEM. SOC., Vol. 117, No. 37, (1995), P. ORDOUKHANIAN et al., "Design and Synthesis of Aversatile Photocleavage DNA Building Block. Application to Phototriggered Hybridization", p. 9570-9571.
NUCLEIC ACIDS RES., Vol. 21, No. 18, (1993), M. PUTTARAJU et al., "A Circular Trans-Acting Hepatitis Delta Virus Ribozyme", p. 4253-4258.
ARCH. INT. PHYSIOL. BIOCHEM., Vol. 87, No. 5, (1979), J. PIETTE, "Guanine Alteration and Production of Strand Breaks in DNA Photosensitized by Proflavine", p. 1050-1051.
PHOTOCHEM. PHOTOBIOL., Vol. 62, No. 1, (1995), G. CONDORELLI et al., "Molecular Mechanism of Drug Photosensitization 7. Photocleavage of DNA Sensitized by Suprofen", p. 155-161.
See also references of EP 0855403A4
NUCLEIC ACIDS RES., Vol. 21, No. 18, (1993), M. PUTTARAJU et al., "A Circular Trans-Acting Hepatitis Delta Virus Ribozyme", p. 4253-4258.
ARCH. INT. PHYSIOL. BIOCHEM., Vol. 87, No. 5, (1979), J. PIETTE, "Guanine Alteration and Production of Strand Breaks in DNA Photosensitized by Proflavine", p. 1050-1051.
PHOTOCHEM. PHOTOBIOL., Vol. 62, No. 1, (1995), G. CONDORELLI et al., "Molecular Mechanism of Drug Photosensitization 7. Photocleavage of DNA Sensitized by Suprofen", p. 155-161.
See also references of EP 0855403A4
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