Title:
PHYSIOLOGICALLY ACTIVE GLYCOLIPID
Document Type and Number:
WIPO Patent Application WO/2007/069603
Kind Code:
A1
Abstract:
The object is to isolate phosphatidylglucoside (a hysiologically active glycolipid) and an acetylated form of the glycolipid from the brain of a fetal rat, determining the structures of these compounds and evaluating the physiological activities of these compounds. Thus, disclosed is a glycolipid represented by the formula (1).
Inventors:
NAGATSUKA YASUKO (JP)
HIRABAYASHI YOSHIO (JP)
KAMIGUCHI HIROYUKI (JP)
HIRABAYASHI YOSHIO (JP)
KAMIGUCHI HIROYUKI (JP)
Application Number:
PCT/JP2006/324756
Publication Date:
June 21, 2007
Filing Date:
December 12, 2006
Export Citation:
Assignee:
RIKEN (JP)
NAGATSUKA YASUKO (JP)
HIRABAYASHI YOSHIO (JP)
KAMIGUCHI HIROYUKI (JP)
NAGATSUKA YASUKO (JP)
HIRABAYASHI YOSHIO (JP)
KAMIGUCHI HIROYUKI (JP)
International Classes:
C07H11/04; A61K31/7028; A61P25/00; A61P43/00; G01N33/53
Foreign References:
| JPH02273536A | 1990-11-08 | |||
| JPS6391089A | 1988-04-21 |
Other References:
NAGATSUKA Y. ET AL.: "Phosphatidylglucoside Exists as a Single Molecular Species with Saturated Fatty Acyl Chains in Developing Astroglial Membranes", BIOCHEMISTRY, vol. 45, 2006, pages 8742 - 8750, XP003014485
ANTONOPOULOU S. ET AL.: "Bioactive polar lipids from Chroococcidiopsis sp. (Cyanobacteria)", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, PART B, 2005, pages 269 - 282, XP003014486
NAGATSUKA Y. ET AL.: "A new phosphoglycerolipid, 'phosphatidylglucose', found in human cord red cells by multi-reactive monoclonal anti-i cold agglutinin, mAb GL-1/GL-2", FEBS LETTERS, vol. 497, 2001, pages 141 - 147, XP003014487
SCHMIDT R.R. ET AL.: "Glycosylimidate, 10 Glycosylphosphate aus Glycosyl(trichloroacetimidaten)", LIEBIGS ANN. CHEM., 1984, pages 680 - 691, XP003014488
ANTONOPOULOU S. ET AL.: "Bioactive polar lipids from Chroococcidiopsis sp. (Cyanobacteria)", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, PART B, 2005, pages 269 - 282, XP003014486
NAGATSUKA Y. ET AL.: "A new phosphoglycerolipid, 'phosphatidylglucose', found in human cord red cells by multi-reactive monoclonal anti-i cold agglutinin, mAb GL-1/GL-2", FEBS LETTERS, vol. 497, 2001, pages 141 - 147, XP003014487
SCHMIDT R.R. ET AL.: "Glycosylimidate, 10 Glycosylphosphate aus Glycosyl(trichloroacetimidaten)", LIEBIGS ANN. CHEM., 1984, pages 680 - 691, XP003014488
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo 31, JP)
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