Title:
PLANAR PATCH CLAMP DEVICE, ELECTRODES FOR SAID DEVICE AND CELL ION CHANNEL CURRENT MEASUREMENT METHOD
Document Type and Number:
WIPO Patent Application WO/2013/094418
Kind Code:
A1
Abstract:
In order to reduce a noise current by suppressing variations in an applied membrane potential in a planar patch clamp device, enabling an ion channel current to be accurately measured, this planar patch clamp device is provided with a liquid reservoir that has at least one fine through-hole disposed on an electrically insulative substrate, and holds a conductive liquid on surfaces on both sides of the through-hole; and electrodes, which are capable of being energized, are disposed in said liquid reservoir. The electrodes are provided with: (a) an electrode vessel, wherein part of the vessel wall comprises an inorganic porous material; (b) an electrode, wherein a noble metal chloride (NmCl) layer is formed on the surface of the noble metal (Nm); and (c) an electrode solution, wherein the noble metal chloride and an alkali metal chloride are dissolved at a saturated concentration.
Inventors:
URISU TSUNEO (JP)
WANG ZHI-HONG (JP)
UNO HIDETAKA (JP)
OBULIRAJ SENTHIL KUMAR (JP)
NAGAOKA YASUTAKA (JP)
WANG ZHI-HONG (JP)
UNO HIDETAKA (JP)
OBULIRAJ SENTHIL KUMAR (JP)
NAGAOKA YASUTAKA (JP)
Application Number:
PCT/JP2012/081556
Publication Date:
June 27, 2013
Filing Date:
December 05, 2012
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
International Classes:
G01N27/28; C12M1/34; C12Q1/02; G01N27/00; G01N27/416
Foreign References:
| JP2009195107A | 2009-09-03 | |||
| JP2008039624A | 2008-02-21 | |||
| JP2003511668A | 2003-03-25 | |||
| JP2005536751A | 2005-12-02 | |||
| JP2009204407A | 2009-09-10 | |||
| JP2008046145A | 2008-02-28 |
Other References:
TSUNEO URISU ET AL., ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 391, 2008, pages 2703 - 2709
PHILIPP SCHOENENBERGER ET AL., BRAIN CELL BIOLOGY, vol. 36, 2008, pages 119
CHR-WR: HONGXIA WANG ET AL., J. BIOL. CHEM., vol. 284, 2009, pages 5685
JONATHAN ERICKSON ET AL., JOURNAL OF NEUROSCIENCE METHODS, vol. 175, 2008, pages 1 - 16
See also references of EP 2801820A4
PHILIPP SCHOENENBERGER ET AL., BRAIN CELL BIOLOGY, vol. 36, 2008, pages 119
CHR-WR: HONGXIA WANG ET AL., J. BIOL. CHEM., vol. 284, 2009, pages 5685
JONATHAN ERICKSON ET AL., JOURNAL OF NEUROSCIENCE METHODS, vol. 175, 2008, pages 1 - 16
See also references of EP 2801820A4
Attorney, Agent or Firm:
KITAGAWA Osamu et al. (JP)
Kitagawa 治 (JP)
Kitagawa 治 (JP)
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Claims:
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