Title:
PLGA PREPARATION CONTAINING ANTIMICROBIAL
Document Type and Number:
WIPO Patent Application WO/2023/171588
Kind Code:
A1
Abstract:
By administering a PLGA preparation in which an antimicrobial is bonded outwardly to the surface of PLGA particles, the antimicrobial is less likely to be taken up by the reticuloendothelial system, the toxicity can also be reduced, residence in the blood can be maintained, and the antimicrobial action can be heightened.
Inventors:
MATSUZAKI TAKASHI (JP)
MAKI HIDEKI (JP)
YOSHIDA OSAMU (JP)
HOMMA TOMOYUKI (JP)
MAKI HIDEKI (JP)
YOSHIDA OSAMU (JP)
HOMMA TOMOYUKI (JP)
Application Number:
PCT/JP2023/008202
Publication Date:
September 14, 2023
Filing Date:
March 06, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
SHIONOGI & CO (JP)
SHIONOGI & CO (JP)
International Classes:
A61K47/59; B25J9/10
Domestic Patent References:
| WO2012169518A1 | 2012-12-13 |
Foreign References:
| JP2010031003A | 2010-02-12 | |||
| JP2014505695A | 2014-03-06 | |||
| JP2019518733A | 2019-07-04 | |||
| JP2018505910A | 2018-03-01 | |||
| JP2017533218A | 2017-11-09 |
Other References:
YURTDAŞ-KIRIMLIOĞLU GÜLSEL, GÖRGÜLÜ ŞENNUR: "Surface modification of PLGA nanoparticles with chitosan or Eudragit® RS 100: Characterization, prolonged release, cytotoxicity, and enhanced antimicrobial activity", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol. 61, 1 February 2021 (2021-02-01), FR , pages 102145, XP093090889, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2020.102145
ÖZTÜRK A. ALPER, YENILMEZ EVRIM, ÖZARDA MUSTAFA GÜÇLÜ: "Clarithromycin-Loaded Poly (Lactic-co-glycolic Acid) (PLGA) Nanoparticles for Oral Administration: Effect of Polymer Molecular Weight and Surface Modification with Chitosan on Formulation, Nanoparticle Characterization and Antibacterial Effects", POLYMERS, vol. 11, no. 10, pages 1632, XP093090898, DOI: 10.3390/polym11101632
ÖZTÜRK A. ALPER, YENILMEZ EVRIM, ÖZARDA MUSTAFA GÜÇLÜ: "Clarithromycin-Loaded Poly (Lactic-co-glycolic Acid) (PLGA) Nanoparticles for Oral Administration: Effect of Polymer Molecular Weight and Surface Modification with Chitosan on Formulation, Nanoparticle Characterization and Antibacterial Effects", POLYMERS, vol. 11, no. 10, pages 1632, XP093090898, DOI: 10.3390/polym11101632
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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