Title:
PLPRO PROTEIN INHIBITOR, AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/208171
Kind Code:
A1
Abstract:
Disclosed in the present invention are a PLpro protease inhibitor, and a preparation method and application thereof. The PLpro protease inhibitor can be combined with one or more pharmaceutically acceptable auxiliary materials or one or more other active ingredients to serve as a PLpro inhibitor to treat diseases caused by or diseases related to virus infection. The auxiliary material can be a carrier, a diluent, an adhesive, a lubricant, a wetting agent, etc. The protease inhibitor has high inhibitory activity, and can be used for broad-spectrum antivirals, especially for coronaviruses, for example, HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU, SARS-CoV, MERS-CoV, SARS-CoV-2, etc., in particular SARS-CoV, MERS-CoV, SARS-CoV-2.
Inventors:
HE WEI (CN)
WU CAI (CN)
LI BIN (CN)
LI HAOXIANG (CN)
ZHENG JIQING (CN)
WAN SHIZHANG (CN)
XU LIQIAN (CN)
WANG MEIJING (CN)
LIU KAI (CN)
XU CHENHAO (CN)
LIANG E (CN)
LIU LEI (CN)
WU CAI (CN)
LI BIN (CN)
LI HAOXIANG (CN)
ZHENG JIQING (CN)
WAN SHIZHANG (CN)
XU LIQIAN (CN)
WANG MEIJING (CN)
LIU KAI (CN)
XU CHENHAO (CN)
LIANG E (CN)
LIU LEI (CN)
Application Number:
PCT/CN2023/091481
Publication Date:
November 02, 2023
Filing Date:
April 28, 2023
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C07D205/04; A61K31/166; A61K31/17; A61K31/18; A61K31/44; A61K31/505; A61P31/14; C07D213/81; C07D213/82; C07D239/80
Foreign References:
| CN114957165A | 2022-08-30 | |||
| CN114957110A | 2022-08-30 | |||
| CN108929263A | 2018-12-04 | |||
| CN102089278A | 2011-06-08 |
Other References:
ZHAO YAO, DU XIAOYU, DUAN YINKAI, PAN XIAOYAN, SUN YIFANG, YOU TIAN, HAN LIN, JIN ZHENMING, SHANG WEIJUAN, YU JING, GUO HANGTIAN, : "High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors", PROTEIN & CELL, SPRINGER ASIA, BEIJING, CN, vol. 12, no. 11, 17 November 2021 (2021-11-17), Beijing, CN , pages 877 - 888, XP055869891, ISSN: 1674-800X, DOI: 10.1007/s13238-021-00836-9
Attorney, Agent or Firm:
BEIJING IPLING INTELLECTUAL PROPERTY LAW FIRM (CN)
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