Title:
PROTEASE INHIBITOR, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/208170
Kind Code:
A1
Abstract:
Provided are a protease inhibitor, a method for preparing same, and use thereof. The protease inhibitor can be combined with one or more pharmaceutically acceptable excipients or one or more other active ingredients to be used as a PLpro inhibitor to treat diseases or conditions caused by viral infections or related to viral infections. The excipients can be a carrier, a diluent, an adhesive, a lubricant, a wetting agent, and the like. The protease inhibitor has high inhibitory activity, and can be used for broad-spectrum anti-virus, especially coronaviruses, for example, HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU, SARS-CoV, MERS-CoV, SARS-CoV-2, and the like, in particular SARS-CoV, MERS-CoV, and SARS-CoV-2.
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Inventors:
HE WEI (CN)
WU CAI (CN)
LI BIN (CN)
LI HAOXIANG (CN)
ZHENG JIQING (CN)
WAN SHIZHANG (CN)
XU LIQIAN (CN)
WANG MEIJING (CN)
LIU KAI (CN)
XU CHENHAO (CN)
LIANG E (CN)
LIU LEI (CN)
WU CAI (CN)
LI BIN (CN)
LI HAOXIANG (CN)
ZHENG JIQING (CN)
WAN SHIZHANG (CN)
XU LIQIAN (CN)
WANG MEIJING (CN)
LIU KAI (CN)
XU CHENHAO (CN)
LIANG E (CN)
LIU LEI (CN)
Application Number:
PCT/CN2023/091480
Publication Date:
November 02, 2023
Filing Date:
April 28, 2023
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C07D487/10; A61K31/397; A61K31/495; A61K31/499; A61K31/5375; A61K31/54; A61P31/14; C07C233/65; C07D205/04; C07D241/08; C07D265/30; C07D279/12
Domestic Patent References:
| WO2020096871A1 | 2020-05-14 |
Foreign References:
| CN114957110A | 2022-08-30 | |||
| CN114957165A | 2022-08-30 |
Other References:
DATABASE Registry 8 July 2015 (2015-07-08), ANONYMOUS : "2-Pyrazinecarboxamide, N-[1-(1-naphthalenyl)cyclopropyl]- (CA INDEX NAME)", XP093104939, retrieved from STNext Database accession no. 1328699-54-2
WANG YIFEI, QIAO JINGXIN; LI WENPEI; LI LINLI: "Virtual screening and bioactivity evaluation of SARS-CoV-2 papain-like protease inhibitors ", WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 37, no. 1, 15 February 2022 (2022-02-15), pages 1 - 5, XP093104940
XINYUE FANG, YINGLI WU: "Papain-like proteases of SARS-CoV-2 and its current inhibitors", CHEMISTRY OF LIFE, vol. 41, no. 8, 25 August 2021 (2021-08-25), pages 1784 - 1795, XP093105284, DOI: 10.13488/j.smhx.20210156
RATIA, K. ET AL.: "A Noncovalent Class of Papain-Like Protease/Deubiquitinase Inhibitors Blocks SARS Virus Replication", PNAS, vol. 105, no. 42, 21 October 2008 (2008-10-21), XP055887377, DOI: 10.1073/pnas.0805240105
WANG YIFEI, QIAO JINGXIN; LI WENPEI; LI LINLI: "Virtual screening and bioactivity evaluation of SARS-CoV-2 papain-like protease inhibitors ", WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 37, no. 1, 15 February 2022 (2022-02-15), pages 1 - 5, XP093104940
XINYUE FANG, YINGLI WU: "Papain-like proteases of SARS-CoV-2 and its current inhibitors", CHEMISTRY OF LIFE, vol. 41, no. 8, 25 August 2021 (2021-08-25), pages 1784 - 1795, XP093105284, DOI: 10.13488/j.smhx.20210156
RATIA, K. ET AL.: "A Noncovalent Class of Papain-Like Protease/Deubiquitinase Inhibitors Blocks SARS Virus Replication", PNAS, vol. 105, no. 42, 21 October 2008 (2008-10-21), XP055887377, DOI: 10.1073/pnas.0805240105
Attorney, Agent or Firm:
BEIJING IPLING INTELLECTUAL PROPERTY LAW FIRM (CN)
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