Title:
PLURIPOTENT STEM CELLS AND METHOD OF STIMULATING AND EXTRACTING NON-EMBRYONIC PLURIPOTENT STEM CELLS FROM MAMMAL BLOOD AND USING RECONSTITUTED PLURIPOTENT STEM CELLS TO TREAT DISEASES INCLUDING CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Document Type and Number:
WIPO Patent Application WO/2012/106367
Kind Code:
A3
Abstract:
Stimulating tissue resident pluripotent stem cells in a manner that the respective subject (e.g., human) acts as its own sterile bioreactor for in vivo stem cell proliferation thus eliminating the need to isolate, cultivate, maintain, proliferate and release stem cells ex vivo. The stimulation mobilizes excess pluripotent stem cells into the peripheral vasculature where the pluripotent stem cells can either migrate to damaged tissues and/or be harvested by simple venipuncture, thus eliminating potential morbidity and mortality elicited from harvesting tissue from solid tissue sites. The pluripotent stem cells are separated from the blood by gravity sedimentation, after which the pluripotent stem cells can easily be aspirated from the white blood cells and red blood cells. Billions of pluripotent stem cells can be generated in this fashion for infusion/injection into the body, via the vasculature, and into the organ(s) in need of tissue repair and regeneration.
Inventors:
ROYAL DANIEL F (US)
YOUNG HENRY E (US)
DYAL SETH (US)
YOUNG HENRY E (US)
DYAL SETH (US)
Application Number:
PCT/US2012/023382
Publication Date:
September 20, 2012
Filing Date:
January 31, 2012
Export Citation:
Assignee:
ROYAL DANIEL F (US)
YOUNG HENRY E (US)
DYAL SETH (US)
YOUNG HENRY E (US)
DYAL SETH (US)
International Classes:
A61K35/74; A61K35/12; A61K35/16; A61K35/545; A61K35/66; A61P11/00; C12N5/074
Foreign References:
| US20080138321A1 | 2008-06-12 | |||
| US20100068189A1 | 2010-03-18 |
Other References:
DONG HWAN KIM ET AL.: "Similar outcomes of cryopreserved allogeneic peripheral stem cell transplants (PBSCT) compared to fresh allografts", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, vol. 13, no. 10, 2007, pages 1233 - 1243, XP022261000
DAVID M. BODINE ET AL.: "In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells", BLOOD, vol. 82, no. 2, 1993, pages 445 - 455, XP002963459
DAVID M. BODINE ET AL.: "In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells", BLOOD, vol. 82, no. 2, 1993, pages 445 - 455, XP002963459
Attorney, Agent or Firm:
PHILLIPS, Rob L. (2450 Colorado Avenue Suite 400 EastSanta Monica, California, US)
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