Title:
PODATE LIGANDS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2001042220
Kind Code:
A3
Abstract:
The invention provides a novel podate ligand H4L<1>[1,2,4,5-tetrakis(pyrazol-1-ylmethyl-3-carboxylic acid)benzene] and to complexes comprising the ligand and a metal ion. Pharmaceutical compositions and methods of making and using the metal-podate complex for enhancement of diagnostic imaging are also described.
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Inventors:
BUNZLI JEAN-CLAUDE (CH)
FATIN-ROUGE NICOLAS (CH)
FATIN-ROUGE NICOLAS (CH)
Application Number:
PCT/IB2000/001988
Publication Date:
March 07, 2002
Filing Date:
December 13, 2000
Export Citation:
Assignee:
UNIV LAUSANNE (CH)
BUNZLI JEAN CLAUDE (CH)
FATIN ROUGE NICOLAS (CH)
BUNZLI JEAN CLAUDE (CH)
FATIN ROUGE NICOLAS (CH)
International Classes:
A61K49/00; A61K49/10; A61K51/04; C07D231/14; C07F5/00; (IPC1-7): C07D231/14; A61K31/415; C07F9/94
Other References:
FATIN-ROUGE, NICOLAS ET AL: "Lanthanide Podates with Programmed Intermolecular Interactions: Luminescence Enhancement through Association with Cyclodextrins and Unusually Large Relaxivity of the Gadolinium Self-Aggregates", J. AM. CHEM. SOC. (2000), 122(44), 10810-10820, XP002167994
REEVES, ZOE R. ET AL: "Lanthanide complexes of a new sterically hindered potentially hexadentate podand ligand based on a tris(pyrazolyl)borate core;crystal structures, solution structures and luminescence properties", J. CHEM. SOC., DALTON TRANS. (1999), (3), 349-356, XP002167995
ZUCCHI, GAEL ET AL: "Structural and photophysical behavior of lanthanide complexes with a tetraazacyclododecane featuring carbamoyl pendant arms", J. CHEM. SOC., DALTON TRANS. (1999), (6), 931-938, XP002167996
HARTSHORN, CHRIS M. ET AL: "Cyclometalated Compounds. XI. Single and Double Cyclometalations of Poly(pyrazolylmethyl)benzenes", ORGANOMETALLICS (1998), 17(16), 3487-3496, XP000999856
HARTSHORN, CHRIS M. ET AL: "Serendipitous isolation of a trinuclear silver complex containing a bridging tridentate cyanide", AUST. J. CHEM. (1997), 50(12), 1195-1198, XP001000023
HARTSHORN, CHRIS M. ET AL: "Poly(pyrazol-1-ylmethyl)benzenes: new multidentate ligands", AUST. J. CHEM. (1995), 48(9), 1587-99, XP001000022
C HARTSHORN ET AL: "Coelenterands: A new class of metal-encapsulating ligands", ANGEWANDT. CHEM INT ED, vol. 35, no. 22, 1996, pages 2655 - 2657, XP000999126
REEVES, ZOE R. ET AL: "Lanthanide complexes of a new sterically hindered potentially hexadentate podand ligand based on a tris(pyrazolyl)borate core;crystal structures, solution structures and luminescence properties", J. CHEM. SOC., DALTON TRANS. (1999), (3), 349-356, XP002167995
ZUCCHI, GAEL ET AL: "Structural and photophysical behavior of lanthanide complexes with a tetraazacyclododecane featuring carbamoyl pendant arms", J. CHEM. SOC., DALTON TRANS. (1999), (6), 931-938, XP002167996
HARTSHORN, CHRIS M. ET AL: "Cyclometalated Compounds. XI. Single and Double Cyclometalations of Poly(pyrazolylmethyl)benzenes", ORGANOMETALLICS (1998), 17(16), 3487-3496, XP000999856
HARTSHORN, CHRIS M. ET AL: "Serendipitous isolation of a trinuclear silver complex containing a bridging tridentate cyanide", AUST. J. CHEM. (1997), 50(12), 1195-1198, XP001000023
HARTSHORN, CHRIS M. ET AL: "Poly(pyrazol-1-ylmethyl)benzenes: new multidentate ligands", AUST. J. CHEM. (1995), 48(9), 1587-99, XP001000022
C HARTSHORN ET AL: "Coelenterands: A new class of metal-encapsulating ligands", ANGEWANDT. CHEM INT ED, vol. 35, no. 22, 1996, pages 2655 - 2657, XP000999126
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