POLY[ALPHA-CYANOACRYLATE] HYDROLYZATE AND PREPARATION METHOD AND APPLICAITON THEREOF

Title:

POLY[ALPHA-CYANOACRYLATE] HYDROLYZATE AND PREPARATION METHOD AND APPLICAITON THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/043004

Kind Code:

A1

Abstract:

Provided are a poly[α-cyanoacrylate] hydrolyzate and a preparation method and an application thereof, which belong to the field of pharmaceutical and chemical industry. A key technical solution is as follows: poly[α-cyanoacrylate] hydrolyzate, the chemical formula is: formula (I), R=-CN or -COOH. Poly[2-cyanoacrylic acid] is dispersed in water to form negatively charged microspheres, that is, to obtain blank embolic microspheres, particle size thereof can be adjusted in the micron-scale range, and the microspheres have a deformation function to pass through a blood vessel with specific shape, which can tightly embolize the blood vessel to avoid ectopic embolism caused by falling off; the poly[2-carboxyacrylic acid] can be used for preparing a novel nano medicine carrier, which can improve the curative effect of the carried medicine on diseased tissues, and reduce toxic and side effects of the carried medicine on normal tissues.

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Inventors:

WANG JUNPING (CN)
GUO YIN (CN)

Application Number:

PCT/CN2020/110386

Publication Date:

March 11, 2021

Filing Date:

August 21, 2020

Export Citation:

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Assignee:

DALIAN HEYUAN MEDICAL EQUIPMENTS CO LTD (CN)

International Classes:

C08F122/00; A61K9/50; A61K47/32; C08F8/00; C08F8/12; C08F120/50

Foreign References:

CN110498877A	2019-11-26
CN110527007A	2019-12-03
CN1424919A	2003-06-18
US4013703A	1977-03-22
CN103031122A	2013-04-10
CN101234217A	2008-08-06
US20100196280A1	2010-08-05

Attorney, Agent or Firm:

DALIAN CHICCO PATENT OFFICE (CN)

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