Title:
POLYETHYLENE GLYCOL DERIVATIVE, PREPARATION METHOD THEREFOR, AND POLYETHYLENE GLYCOL HYDROGEL ENABLING FAST CROSSLINKING REACTION
Document Type and Number:
WIPO Patent Application WO/2021/237864
Kind Code:
A1
Abstract:
A polyethylene glycol derivative, comprising a repeating unit having a structure of formula (I) and a terminal group having a structure of formula (II). The provided polyethylene glycol derivative has good biocompatibility due to the repeating unit having the structure of formula (I). Because the phthalaldehyde terminal group having the structure of formula (II) can react with various groups such as amino, hydrazide group, and aminooxy group, the reaction rate is fast, and the reaction conditions are mild. A chemically crosslinked hydrogel material can be formed quickly by mixing in an aqueous medium the provided polyethylene glycol derivative and polyethylene glycol having terminal groups comprising amino group, the preparation conditions are mild, the gel forming speed is fast, and a high mechanical strength and a good stability are achieved. The polyethylene glycol hydrogel can be used as a sustained-release drug carrier or a tissue engineering stent in the field of biomedical materials.
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Inventors:
HE CHAOLIANG (CN)
ZHANG ZHEN (CN)
REN HUI (CN)
CHEN XUESI (CN)
ZHANG ZHEN (CN)
REN HUI (CN)
CHEN XUESI (CN)
Application Number:
PCT/CN2020/098863
Publication Date:
December 02, 2021
Filing Date:
June 29, 2020
Export Citation:
Assignee:
CHANGCHUN INST APPLIED CHEMISTRY CAS (CN)
International Classes:
C08G65/333; A61K9/06; A61K47/10; A61K47/18; A61L24/00; A61L24/04; A61L27/18; A61L27/52; C07D405/12; C08J3/075; C08L71/02
Foreign References:
| CN107596438A | 2018-01-19 | |||
| CN110157011A | 2019-08-23 | |||
| CN106832060A | 2017-06-13 | |||
| CN108822299A | 2018-11-16 | |||
| US20160206748A1 | 2016-07-21 |
Other References:
ZHANG ZHEN, HE CHAOLIANG, RONG YAN, REN HUI, WANG TIANRAN, ZOU ZHENG, CHEN XUESI: "A fast and versatile cross-linking strategy via o -phthalaldehyde condensation for mechanically strengthened and functional hydrogels", NATIONAL SCIENCE REVIEW, vol. 8, no. 4, 24 April 2021 (2021-04-24), XP055871567, ISSN: 2095-5138, DOI: 10.1093/nsr/nwaa128
See also references of EP 3974462A4
See also references of EP 3974462A4
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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