POLYMER COMPOSITE FOR HELICOBACTER PYLORI RECOGNITION AND COMPOSITION FOR PHOTODYNAMIC THERAPY COMPRISING SAME - CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION

Title:

POLYMER COMPOSITE FOR HELICOBACTER PYLORI RECOGNITION AND COMPOSITION FOR PHOTODYNAMIC THERAPY COMPRISING SAME

Document Type and Number:

WIPO Patent Application WO/2020/060260

Kind Code:

A1

Abstract:

The present invention relates to a polymer composite for Helicobacter pylori recognition and a use of same. In particular, the present invention has confirmed that a water-soluble polymer-photosensitizer composite coupled to sialyl lactose that selectively binds to the surface of Helicobacter pylori exhibits desirable selectivity and binding strength to Helicobacter pylori strains, and upon laser irradiation, the photosensitizer within the composite generates singlet oxygen, thus effectively inducing the inactivation of Helicobacter pylori. Accordingly, by providing the composite as a polymer composite for Helicobacter pylori recognition, the present invention provides a Helicobacter pylori photodynamic therapy agent to enable an effective detection of Helicobacter pylori in the gastrointestinal tract while addressing antibiotic resistance issues of the conventional art.

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Inventors:

NA KUN (KR)
IM BYEONG NAM (KR)

Application Number:

PCT/KR2019/012197

Publication Date:

March 26, 2020

Filing Date:

September 20, 2019

Export Citation:

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Assignee:

CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)

International Classes:

A61K41/00; A61K47/54; A61K47/56; A61P1/00; A61P31/04; G01N33/569

Foreign References:

KR20180085689A	2018-07-27
KR20170104024A	2017-09-14
KR20160127360A	2016-11-04

Other References:

PARENTE, F.: "Treatment of Helicobacter pylori infection using a novel antiadhesion compound (3'sialyllactose sodium salt). A double blind, placebo-controlled clinical study", HELICOBACTER, 2003, pages 252 - 256, XP055693791
SAHU, K.: "Topical photodynamic treatment with poly-L-lysine-chlorin p6 conjugate improves wound healing by reducing hyper inflammatory response in Pseudomonas aeruginosa-infected wounds of mice", LASERS MED SCI., 2013, pages 465 - 471, XP055571792

Attorney, Agent or Firm:

TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)

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