Title:
POLYPEPTIDE CAPABLE OF BONDING TO TARGET MOLECULE
Document Type and Number:
WIPO Patent Application WO/2019/198693
Kind Code:
A1
Abstract:
A polypeptide which comprises any one of the amino acid sequences (i) to (xi) and of which the bondability to a target molecule is increased compared with a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 1.
AHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGA (SEQ ID NO: 1)
Inventors:
ITO TOMOYUKI (JP)
NISHI HAFUMI (JP)
NAKAZAWA HIKARU (JP)
NIIDE TEPPEI (JP)
UMETSU MITSUO (JP)
KAMEDA TOMOSHI (JP)
NISHI HAFUMI (JP)
NAKAZAWA HIKARU (JP)
NIIDE TEPPEI (JP)
UMETSU MITSUO (JP)
KAMEDA TOMOSHI (JP)
Application Number:
PCT/JP2019/015393
Publication Date:
October 17, 2019
Filing Date:
April 09, 2019
Export Citation:
Assignee:
UNIV TOHOKU (JP)
AIST (JP)
AIST (JP)
International Classes:
C12N15/12; C07K14/47
Other References:
ITO, T. ET AL.: "Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF65", THE EMBO JOURNAL, vol. 18, no. 16, 16 August 1999 (1999-08-16), pages 4523 - 4534, XP055643258
DATABASE Uniprot [online] 28 March 2018 (2018-03-28), Database accession no. A0A2D0S4T9
DATABASE Uniprot [online] 28 March 2018 (2018-03-28), Database accession no. Q6P022
VAZQUEZ-LOMBARDI, R. ET AL.: "Challenges and opportunities for non-antibody scaffold drugs", DRUG DISCOVERY TODAY, vol. 20, no. 10, 2015, pages 1271 - 1283, XP055365149, DOI: 10.1016/j.drudis.2015.09.004
DATABASE Uniprot [online] 28 March 2018 (2018-03-28), Database accession no. A0A2D0S4T9
DATABASE Uniprot [online] 28 March 2018 (2018-03-28), Database accession no. Q6P022
VAZQUEZ-LOMBARDI, R. ET AL.: "Challenges and opportunities for non-antibody scaffold drugs", DRUG DISCOVERY TODAY, vol. 20, no. 10, 2015, pages 1271 - 1283, XP055365149, DOI: 10.1016/j.drudis.2015.09.004
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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