Title:
POLYPEPTIDE COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/206587
Kind Code:
A1
Abstract:
A polypeptide compound having a structure shown in formula I, or a stereoisomer, mixture or pharmaceutically acceptable salt thereof. Experimental results show that the polypeptide compound can effectively exhibit high agonistic activity to GHSR-1a.
Inventors:
MENG GUANGPENG (CN)
FU XIAOPING (CN)
LI SIJUN (CN)
MA HAOYU (CN)
ZHANG YIN (CN)
LIU SHUANG (CN)
XU MIAO (CN)
GAO JIAN (CN)
LI YUANBO (CN)
FU XIAOPING (CN)
LI SIJUN (CN)
MA HAOYU (CN)
ZHANG YIN (CN)
LIU SHUANG (CN)
XU MIAO (CN)
GAO JIAN (CN)
LI YUANBO (CN)
Application Number:
PCT/CN2022/082973
Publication Date:
October 06, 2022
Filing Date:
March 25, 2022
Export Citation:
Assignee:
CHENGDU SINTANOVO BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K7/06; A61K38/07; A61K38/08; A61P5/06; C07K5/117
Domestic Patent References:
| WO2007041278A2 | 2007-04-12 | |||
| WO2009020643A2 | 2009-02-12 | |||
| WO2017197328A1 | 2017-11-16 |
Foreign References:
| CN113072617A | 2021-07-06 | |||
| CN113045625A | 2021-06-29 | |||
| CN101108875A | 2008-01-23 | |||
| CN202110343062A | 2021-03-30 |
Other References:
BOWERS, ENDOCRINOLOGY, vol. 114, 1984, pages 1537 - 1545
STEWART J. M.YOUNG J. D.: "Solid Phase Peptide Synthesis", 1984, PIERCE CHEMICAL COMPANY
BODANZSKY MBODANZSKY A.: "The practice of Peptide Synthesis", 1994, SPRINGER VERLAG
WILLIAMS P. ET AL.: "Chemical Approaches to the Synthesis of Peptides and Proteins", 1997, CRC, BOCA RATON
KULLMANN W.: "Proteases as catalysts for enzymic syntheses of opioid peptides", J. BIOL. CHEM., vol. 255, no. 17, 1980, pages 8234 - 8238, XP002263435
LLOYD-WILLIAMS P ET AL.: "Convergent Solid-Phase Peptide Synthesis", TETRAHEDRON, vol. 49, no. 48, 1993, pages 11065 - 11133, XP002047668, DOI: 10.1016/S0040-4020(01)81800-7
BARLOS K. ET AL.: "Darstellung geschutzter PeptidFragmente unter Einsatz substituierter Triphenylmethyl Harze", TETRAHEDRON LETT., vol. 30, 1989, pages 3943 - 3946
MATSUEDA G. R ET AL.: "A p-methyl benzhydrylamine resin for improved solid-phase synthesis of peptide amides", PEPTIDES, vol. 2, 1981, pages 4550
BARLOS K ET AL.: "Veresterung von partiell geschutzten PeptidFragmenten mit Harzen Einsatz von 2-Chlorotritylchlorid zur Synthese von LeulGastrin I", TETRAHEDRON LETT., vol. 30, 1989, pages 39473951
ALBERICIO F. ET AL., J. ORG. CHEM., vol. 55, 1990, pages 3730 - 3743
RINK H.: "Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin", TETRAHEDRON LETT., vol. 28, 1987, pages 3787 - 3790, XP000196069, DOI: 10.1016/S0040-4039(00)96384-6
WANG S.S., J. AM. CHEM. SOC, vol. 95, 1973, pages 1328 - 1333
BERGE S. M. ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 119
STEWART J. M.YOUNG J. D.: "Solid Phase Peptide Synthesis", 1984, PIERCE CHEMICAL COMPANY
BODANZSKY MBODANZSKY A.: "The practice of Peptide Synthesis", 1994, SPRINGER VERLAG
WILLIAMS P. ET AL.: "Chemical Approaches to the Synthesis of Peptides and Proteins", 1997, CRC, BOCA RATON
KULLMANN W.: "Proteases as catalysts for enzymic syntheses of opioid peptides", J. BIOL. CHEM., vol. 255, no. 17, 1980, pages 8234 - 8238, XP002263435
LLOYD-WILLIAMS P ET AL.: "Convergent Solid-Phase Peptide Synthesis", TETRAHEDRON, vol. 49, no. 48, 1993, pages 11065 - 11133, XP002047668, DOI: 10.1016/S0040-4020(01)81800-7
BARLOS K. ET AL.: "Darstellung geschutzter PeptidFragmente unter Einsatz substituierter Triphenylmethyl Harze", TETRAHEDRON LETT., vol. 30, 1989, pages 3943 - 3946
MATSUEDA G. R ET AL.: "A p-methyl benzhydrylamine resin for improved solid-phase synthesis of peptide amides", PEPTIDES, vol. 2, 1981, pages 4550
BARLOS K ET AL.: "Veresterung von partiell geschutzten PeptidFragmenten mit Harzen Einsatz von 2-Chlorotritylchlorid zur Synthese von LeulGastrin I", TETRAHEDRON LETT., vol. 30, 1989, pages 39473951
ALBERICIO F. ET AL., J. ORG. CHEM., vol. 55, 1990, pages 3730 - 3743
RINK H.: "Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin", TETRAHEDRON LETT., vol. 28, 1987, pages 3787 - 3790, XP000196069, DOI: 10.1016/S0040-4039(00)96384-6
WANG S.S., J. AM. CHEM. SOC, vol. 95, 1973, pages 1328 - 1333
BERGE S. M. ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 119
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
Download PDF: