Title:
POLYPEPTIDE SEQUENCE OF KDM6B AND APPLICATION OF KDM6B IN REGULATING AND CONTROLLING FUNCTION OF MESENCHYMAL STEM CELL
Document Type and Number:
WIPO Patent Application WO/2023/097422
Kind Code:
A1
Abstract:
Disclosed in the present invention is an application of lysine(K)‑specific demethylase 6B (KDM6B) in regulating and controlling the function of a mesenchymal stem cell. WDR5 is a co-binding protein for negatively regulating and controlling the functions of KDM6B and the MLL1. WDR5 can form a protein complex with KDM6B to inhibit the function of KDM6B, such that expression and functions of genes are regulated and controlled by regulating and controlling the methylation state of downstream senescence and osteogenesis related genes and gene promoter region histone, and finally the effects of regulating stem cell senescence and differentiation functions and bone/tooth tissue repair and regeneration functions are achieved. For a KDM6B and WDR5 binding region sequence, small-molecule polypeptide is researched, developed, and utilized, and the function of the mesenchymal stem cell is regulated by regulating and controlling the binding of a KDM6B/WDR5 complex.
Inventors:
FAN ZHIPENG (CN)
ZHANG CHEN (CN)
JIANG YU (CN)
LONG LUJUE (CN)
CAO YANGYANG (CN)
ZHANG CHEN (CN)
JIANG YU (CN)
LONG LUJUE (CN)
CAO YANGYANG (CN)
Application Number:
PCT/CN2021/134280
Publication Date:
June 08, 2023
Filing Date:
November 30, 2021
Export Citation:
Assignee:
BEIJING STOMATOLOGICAL HOSPITAL CAPITAL MEDICAL UNIV (CN)
International Classes:
A61K45/00; A61K38/44; A61P19/10; C12N9/02
Foreign References:
| CN111979184A | 2020-11-24 | |||
| CN109734674A | 2019-05-10 | |||
| CN113599522A | 2021-11-05 | |||
| CN104946785A | 2015-09-30 |
Other References:
"Master's Thesis", 1 May 2018, TIANJIN MEDICAL UNIVERSITY, CN, article ZHANG, CHEN: "The Function and Mechanism of WDR5 on the Mesenchymal Stem Cells", pages: 1 - 70, XP009546078
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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