POLYPEPTIDES THAT BIND COMPLEMENT COMPONENT C5 OR SERUM ALBUMIN AND FUSION PROTEINS THEREOF

Title:

POLYPEPTIDES THAT BIND COMPLEMENT COMPONENT C5 OR SERUM ALBUMIN AND FUSION PROTEINS THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/014360

Kind Code:

A8

Abstract:

The disclosure provides engineered polypeptides that specifically bind to human complement component C5 and/or serum albumin. The disclosure also provides fusion proteins comprising such engineered polypeptides, wherein such fusion proteins may be multivalent and multi- specific fusion proteins. The disclosure further provides nucleic acid molecules that encode such engineered polypeptides or fusion proteins, and methods of making such engineered polypeptides or fusion proteins. The disclosure further provides pharmaceutical compositions that comprise such engineered polypeptides or fusion proteins, and methods of treatment using such engineered polypeptides or fusion proteins.

More Like This:

WO/2014/066058	DUAL VARIABLE DOMAIN (DVD) IMMUNOGLOBULINS FOR REDUCING MAJOR ADVERSE CARDIOVASCULAR EVENTS (MACE) IN DIABETIC PATIENTS SUBSEQUENT TO STENT PLACEMENT
JP2008253267	MATERIAL FOR PREPARING MODIFIED ANTIBODY VARIABLE DOMAIN AND THERAPEUTIC USE THEREOF
JPS62500120	[Title of the Invention] A monoclonal antibody to metal chelate

Inventors:

PUFFER BRIDGET (US)
CHANDLER JULIAN (US)
GERA NIMISH (US)
SHERIDAN DOUGLAS (US)
JINDAL SIDDHARTH (US)
TAMBURINI PAUL (US)

Application Number:

PCT/US2018/041661

Publication Date:

February 21, 2019

Filing Date:

July 11, 2018

Export Citation:

Click for automatic bibliography generation Help

Assignee:

ALEXION PHARMA INC (US)

International Classes:

C07K16/46; A61K39/395; C07K16/18

Attorney, Agent or Firm:

REMILLARD, Jane, E. et al. (US)

Download PDF:

View/Download PDF PDF Help

Previous Patent: POLYMERASE CHAIN TRANSCRIPTION (PCT): EXPONENTIAL SYNTHESIS OF RNA AND MODIFIED RNA

Next Patent: SPATIAL LISTEN BEFORE TALK