Title:
POROUS HOLLOW FIBER MEMBRANE AND POROUS HOLLOW FIBER MEMBRANE FOR PROCESSING PROTEIN-CONTAINING LIQUID
Document Type and Number:
WIPO Patent Application WO/2010/074136
Kind Code:
A1
Abstract:
Disclosed is a porous hollow fiber membrane which is capable of efficiently separating and removing a substance to be removed such as a small-diameter virus contained in a solution while simultaneously efficiently transmitting a useful substance to be recovered such as a protein, and for which the decline in the transmittance over time is small. The porous hollow fiber membrane is characterized in that: the filtration downstream surface thereof has dot-shaped or slit-shaped openings; the filtration upstream surface thereof is comprised of a mesh structure or a fine grain aggregate structure; the central region of the membrane thickness portion is comprised of an essentially homogenous structure; the membrane thickness portion is comprised of a structure which essentially does not have macro-voids; the transmission rate for pure water is 10-300 L/(h·m2·bar); and the transmission rate for a 0.1 wt% bovine γ-globulin solution is 30-100% of the transmission rate for pure water. In addition, the membrane is characterized in that the transmission rate for a 0.1 wt%-20 mmol/L phosphate buffer solution of bovine γ-globulin is 30-100% of the transmission rate for a 0.1 wt%-phosphate buffer normal saline solution.
Inventors:
YOKOTA HIDEYUKI (JP)
KATO NORIAKI (JP)
OGAWA HIROFUMI (JP)
MORITA JUNSUKE (JP)
KATO NORIAKI (JP)
OGAWA HIROFUMI (JP)
MORITA JUNSUKE (JP)
Application Number:
PCT/JP2009/071416
Publication Date:
July 01, 2010
Filing Date:
December 24, 2009
Export Citation:
Assignee:
TOYO BOSEKI (JP)
YOKOTA HIDEYUKI (JP)
KATO NORIAKI (JP)
OGAWA HIROFUMI (JP)
MORITA JUNSUKE (JP)
YOKOTA HIDEYUKI (JP)
KATO NORIAKI (JP)
OGAWA HIROFUMI (JP)
MORITA JUNSUKE (JP)
International Classes:
B01D69/08; A61M1/02; A61M1/18; A61M1/34; B01D71/44; B01D71/68; D01F6/76
Domestic Patent References:
| WO2004035180A1 | 2004-04-29 | |||
| WO2003026779A1 | 2003-04-03 |
Foreign References:
| JPS62117812A | 1987-05-29 | |||
| JPS6190672A | 1986-05-08 | |||
| JP2007215569A | 2007-08-30 | |||
| JP2006340977A | 2006-12-21 | |||
| JP2008237893A | 2008-10-09 | |||
| JP2008082728A | 2008-04-10 | |||
| JP2006187768A | 2006-07-20 | |||
| JP2005065725A | 2005-03-17 | |||
| JP2007136449A | 2007-06-07 | |||
| JPH01254204A | 1989-10-11 | |||
| JPH03146067A | 1991-06-21 | |||
| JPH0450054B2 | 1992-08-13 |
Other References:
PDA JOURNAL OF GMP AND VALIDATION IN JAPAN, vol. 7, no. L, 2005, pages 44
PDA JOURNAL OF GMP AND VALIDATION IN JAPAN, vol. 9, no. L, 2007, pages 6
JOURNAL OF MEMBRANE SCIENCE, vol. 210, 2002, pages 369 - 378
JOURNAL OF MEMBRANE SCIENCE, vol. 236, 2004, pages 137 - 144
See also references of EP 2377599A4
PDA JOURNAL OF GMP AND VALIDATION IN JAPAN, vol. 9, no. L, 2007, pages 6
JOURNAL OF MEMBRANE SCIENCE, vol. 210, 2002, pages 369 - 378
JOURNAL OF MEMBRANE SCIENCE, vol. 236, 2004, pages 137 - 144
See also references of EP 2377599A4
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