Title:
PPAR (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR) ACTIVATORS
Document Type and Number:
WIPO Patent Application WO/2002/046176
Kind Code:
A1
Abstract:
Thiazole derivatives represented by the general formula (II) or salts thereof are used as PPAR activators: (II) wherein R?6¿ and R?7¿ are each hydrogen, nitro, C¿1-8? alkyl, C¿6-10? aryl, or the like, or alternatively R?6¿ and R?7¿ together with the carbon atoms to which they are bonded may form a benzene ring; G?1¿ is a single bond or carbonyl; R?8¿ is C¿1-8? alkyl, C¿6-10? aryl, arylalkyl (wherein the aryl moiety contains 6 to 10 carbon atoms and the alkyl moiety contains 1 to 8 carbon atoms), or the like; m is an integer of 0 to 5; Y?1¿ is CH¿2?-, carbonyl, or the like; Z?1¿ is oxygen or sulfur; R?9¿ and R?10¿ are each hydrogen or C¿1-8? alkyl; and R is hydrogen or C¿1-6? alkyl.
Inventors:
YOSHIDA SHINICHI (JP)
SAKUMA SHOGO (JP)
ENDO TSUYOSHI (JP)
TENDO ATSUSHI (JP)
TAKAHASHI TOSHIHIRO (JP)
KOBAYASHI KUNIO (JP)
MOCHIDUKI NOBUTAKA (JP)
YAMAKAWA TOMIO (JP)
KANDA TAKASHI (JP)
MASUI SEIICHIRO (JP)
SAKUMA SHOGO (JP)
ENDO TSUYOSHI (JP)
TENDO ATSUSHI (JP)
TAKAHASHI TOSHIHIRO (JP)
KOBAYASHI KUNIO (JP)
MOCHIDUKI NOBUTAKA (JP)
YAMAKAWA TOMIO (JP)
KANDA TAKASHI (JP)
MASUI SEIICHIRO (JP)
Application Number:
PCT/JP2001/010577
Publication Date:
June 13, 2002
Filing Date:
December 04, 2001
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
YOSHIDA SHINICHI (JP)
SAKUMA SHOGO (JP)
ENDO TSUYOSHI (JP)
TENDO ATSUSHI (JP)
TAKAHASHI TOSHIHIRO (JP)
KOBAYASHI KUNIO (JP)
MOCHIDUKI NOBUTAKA (JP)
YAMAKAWA TOMIO (JP)
KANDA TAKASHI (JP)
MASUI SEIICHIRO (JP)
YOSHIDA SHINICHI (JP)
SAKUMA SHOGO (JP)
ENDO TSUYOSHI (JP)
TENDO ATSUSHI (JP)
TAKAHASHI TOSHIHIRO (JP)
KOBAYASHI KUNIO (JP)
MOCHIDUKI NOBUTAKA (JP)
YAMAKAWA TOMIO (JP)
KANDA TAKASHI (JP)
MASUI SEIICHIRO (JP)
International Classes:
A61P43/00; C07D233/88; C07D233/90; C07D277/42; C07D277/52; C07D277/56; (IPC1-7): C07D277/56; A61K31/4164; A61K31/4184; A61K31/426; A61K31/428; A61P43/00; C07D233/88; C07D233/90; C07D235/24; C07D235/30; C07D277/42; C07D277/68; C07D277/82
Domestic Patent References:
| WO1992010468A1 | 1992-06-25 |
Foreign References:
| US4959379A | 1990-09-25 | |||
| US4151303A | 1979-04-24 | |||
| JPH10182459A | 1998-07-07 |
Other References:
PETER J. BROWN ET AL.: "Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library", CHEMICAL AND BIOLOGY, vol. 4, no. 12, 1997, pages 909 - 918, XP002909095
PETER J. BROWN ET AL.: "Identification of subtype selective human PPAR alpha agonist through parallel-array synthesis", CHEMISTRY AND BIOLOGY, vol. 4, no. 12, 7 May 2001 (2001-05-07), pages 1225 - 1227, XP002909096
PETER J. BROWN ET AL.: "Identification of subtype selective human PPAR alpha agonist through parallel-array synthesis", CHEMISTRY AND BIOLOGY, vol. 4, no. 12, 7 May 2001 (2001-05-07), pages 1225 - 1227, XP002909096
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