Title:
PREDICTIVE FACTOR AND TESTING METHOD FOR THE ONSET OF ARTERIOSCLEROTIC DISEASES
Document Type and Number:
WIPO Patent Application WO/2017/142055
Kind Code:
A1
Abstract:
The present invention provides a diagnostic marker and onset risk evaluation method for arteriosclerotic diseases. More specifically, the present invention provides a method for evaluating the onset risk of an arteriosclerotic disease, wherein the C5a protein in a blood sample is adopted as a diagnostic marker for the arteriosclerotic disease, and the method includes a step for measuring, in vitro, the amount of the C5a protein in a blood sample collected from a subject, and a step for evaluating the onset risk of arteriosclerosis or vascular inflammation in the subject by using the amount of the C5a protein as an indicator. This method is useful for evaluating the onset risk of an arteriosclerotic disease at an extremely early stage.
Inventors:
YOSHIDA MASAYUKI (JP)
OSAKA MIZUKO (JP)
OSAKA MIZUKO (JP)
Application Number:
PCT/JP2017/005836
Publication Date:
August 24, 2017
Filing Date:
February 17, 2017
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV (JP)
International Classes:
G01N33/53; A61K45/00; A61P9/10; G01N33/543; C07K14/47
Domestic Patent References:
| WO2015178237A1 | 2015-11-26 | |||
| WO2013147123A1 | 2013-10-03 | |||
| WO2005007087A2 | 2005-01-27 |
Foreign References:
| JPH08109200A | 1996-04-30 | |||
| JPH10130167A | 1998-05-19 | |||
| JP2010501164A | 2010-01-21 | |||
| JP2013006879A | 2013-01-10 | |||
| JP2015518852A | 2015-07-06 | |||
| JP2011232218A | 2011-11-17 |
Other References:
MIZUKO OSAKA ET AL.: "Atheroma-sei Domyakukokasho no Shinten ni Okeru Hotai Seibun C5a no Yakuwari", ANNUAL SCIENTIFIC MEETING OF THE JAPAN ATHEROSCLEROSIS SOCIETY PROGRAM SHOROKUSHU, vol. 48 th, 30 June 2016 (2016-06-30), pages 229
PATEL S: "ApoE-/- Mice Develop Atherosclerosis in the Absence of Complement Component C5", BIOCHEM BIOPHYS RES COMMUN, vol. 286, no. 1, 10 August 2001 (2001-08-10), pages 164 - 170, XP055409765
TANHEHCO E J: "Sublytic complement attack reduces infarct size in rabbit isolated hearts: evidence for C5a-mediated cardioprotection", IMMUNOPHARMACOLOGY, vol. 49, no. 3, September 2000 (2000-09-01), pages 391 - 399, XP055409767
EMI MITSUI: "Effect of anticomplementary agent (K-76 COONa) on experimental atherosclerosis in rabbits", JOURNAL OF NIHON UNIVERSITY MEDICAL ASSOCIATION, vol. 49, no. 4, April 1990 (1990-04-01), pages 357 - 366, XP001063918
MASANOBU KAWAKAMI: "Cytokine and complication of dialysis patient. Centering on its mechanism. Cytokine and long-term dialysis syndrome. Cytokine and arteriosclerosis", THE JAPANESE JOURNAL OF CLINICAL DIALYSIS, vol. 12, no. 6, June 1996 (1996-06-01), pages 715 - 722
SHAGDARSUREN ERDENECHIMEG: "C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice", CIRCULATION, vol. 122, no. 10, 7 September 2010 (2010-09-07), pages 1026 - 1036, XP055409773
HOVLAND, A: "LDL APHERESIS AND INFLAMMATION - IMPLICATIONS FOR ATHEROSCLEROSIS", SCAND J IMMUNOL, vol. 76, no. 3, September 2012 (2012-09-01), pages 229 - 236, XP055409775
SPEIDL, WALTER S: "ATHEROSCLEROSIS AND COMPLEMENT: ANAPHYLATOXIN C5A AS A NEW RISK MARKER AND THERAPEUTIC TARGET", CLINICAL LIPIDOLOGY, vol. 6, no. 2, 2011, pages 123 - 126, XP055409777
PATEL S: "ApoE-/- Mice Develop Atherosclerosis in the Absence of Complement Component C5", BIOCHEM BIOPHYS RES COMMUN, vol. 286, no. 1, 10 August 2001 (2001-08-10), pages 164 - 170, XP055409765
TANHEHCO E J: "Sublytic complement attack reduces infarct size in rabbit isolated hearts: evidence for C5a-mediated cardioprotection", IMMUNOPHARMACOLOGY, vol. 49, no. 3, September 2000 (2000-09-01), pages 391 - 399, XP055409767
EMI MITSUI: "Effect of anticomplementary agent (K-76 COONa) on experimental atherosclerosis in rabbits", JOURNAL OF NIHON UNIVERSITY MEDICAL ASSOCIATION, vol. 49, no. 4, April 1990 (1990-04-01), pages 357 - 366, XP001063918
MASANOBU KAWAKAMI: "Cytokine and complication of dialysis patient. Centering on its mechanism. Cytokine and long-term dialysis syndrome. Cytokine and arteriosclerosis", THE JAPANESE JOURNAL OF CLINICAL DIALYSIS, vol. 12, no. 6, June 1996 (1996-06-01), pages 715 - 722
SHAGDARSUREN ERDENECHIMEG: "C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice", CIRCULATION, vol. 122, no. 10, 7 September 2010 (2010-09-07), pages 1026 - 1036, XP055409773
HOVLAND, A: "LDL APHERESIS AND INFLAMMATION - IMPLICATIONS FOR ATHEROSCLEROSIS", SCAND J IMMUNOL, vol. 76, no. 3, September 2012 (2012-09-01), pages 229 - 236, XP055409775
SPEIDL, WALTER S: "ATHEROSCLEROSIS AND COMPLEMENT: ANAPHYLATOXIN C5A AS A NEW RISK MARKER AND THERAPEUTIC TARGET", CLINICAL LIPIDOLOGY, vol. 6, no. 2, 2011, pages 123 - 126, XP055409777
Attorney, Agent or Firm:
ITO, Katsuhiro et al. (JP)
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