PREPARATION OF BIOLOGICALLY ACTIVE MOLECULES

WIPO Patent Application WO2000061768

A3

Biologically active molecules are produced from their biologically inactive precursors by mutation of their native cleavage site to a site which is capable of being cleaved by a protease, and cleavage of the mutated molecule to yield a biologically active molecule.

RUBINSTEIN MENACHEM (IL)
LIU BIANLING (IL)
NOVICK DANIELA (IL)
DINARELLO CHARLES (US)
GRABER PIERRE (CH)

PCT/IL2000/000220

February 08, 2001

April 13, 2000

Click for automatic bibliography generation  

YEDA RES & DEV (IL)
RUBINSTEIN MENACHEM (IL)
LIU BIANLING (IL)
NOVICK DANIELA (IL)
DINARELLO CHARLES (US)
GRABER PIERRE (CH)

C07K14/54; C07K14/545; C12N9/64; C12N15/24; C12N15/57; C12N15/02; C12P21/02; C12N; (IPC1-7): C12N15/57; C12N15/24; C12N15/62; C12N9/64; C07K14/54; C07K14/545

WO1998038317A1	1998-09-03
WO1993013208A1	1993-07-08
WO1999007851A1	1999-02-18
WO1997024441A1	1997-07-10

USHIO SHIMPEI ET AL: "Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.", JOURNAL OF IMMUNOLOGY, vol. 156, no. 11, 1996, pages 4274 - 4279, XP002149563, ISSN: 0022-1767
GU YONG ET AL: "Activation of interferon-gamma inducing factor mediated by interleukin-1-beta converting enzyme.", SCIENCE (WASHINGTON D C), vol. 275, no. 5297, 1997, pages 206 - 209, XP002149564, ISSN: 0036-8075
DINARELLO C A: "Interleukin-1", CYTOKINE AND GROWTH FACTOR REVIEWS,GB,OXFORD, vol. 8, no. 4, December 1997 (1997-12-01), pages 253 - 265, XP002098883, ISSN: 1359-6101

View/Download PDF      PDF Help

Previous Patent: EXTRACELLULAR PROTEASE FROM $I(ACREMONIUM CHRYSOGENUM) WITH CPC-ACETYL HYDROLASE ACTIVITY AND ITS UT...

Next Patent: ENHANCEMENT OF THE IMMUNE RESPONSE FOR VACCINE AND GENE THERAPY APPLICATIONS