Title:
PREPARATION OF LACTIC ACID FROM A PENTOSE-CONTAINING SUBSTRATE
Document Type and Number:
WIPO Patent Application WO2004063382
Kind Code:
A3
Abstract:
This invention relates to the production of lactic acid and/or lactate from pentose-containing substrate, particularly from xylose-containing substrate Currently, lactic acid is commercially produced from glucose, starch, liquefied starch or sucrose. At present, these substrates are the most important contributor to the manufacturing cost price of lactic acid. Lignocellulosic biomass offers a cost attractive alternative as a substrate for the biological production of lactic acid because it is readily available, has no competing food value, and is less expensive than either starch or sucrose. We have found that moderately thermophilic Bacillus species are able to ferment pentoses, more specifically xylose to enantiomerically pure lactic acid and/or lactate. Said conversion of pentoses leads to virtually only C3 compounds, i.e. said conversion runs via a homofermentive pathway, which C3 compounds can be recovered as lactic acid and/or lactate.
Inventors:
OTTO ROEL (NL)
Application Number:
PCT/EP2004/050013
Publication Date:
September 23, 2004
Filing Date:
January 12, 2004
Export Citation:
Assignee:
PURAC BIOCHEM BV (NL)
OTTO ROEL (NL)
OTTO ROEL (NL)
International Classes:
C12P7/56; (IPC1-7): C12P7/56
Domestic Patent References:
| WO1997013842A1 | 1997-04-17 |
Foreign References:
| US6022537A | 2000-02-08 |
Other References:
PAYOT T ET AL: "Lactic acid production by Bacillus coagulans - Kinetic studies and optimization of culture medium for batch and continuous fermentations", ENZYME AND MICROBIAL TECHNOLOGY 1999 UNITED STATES, vol. 24, no. 3-4, 1999, pages 191 - 199, XP002240545, ISSN: 0141-0229
OHARA HITOMI ET AL: "L-Lactic acid production by Bacillus sp. in anaerobic and aerobic culture", 1996, JOURNAL OF FERMENTATION AND BIOENGINEERING, VOL. 81, NR. 3, PAGE(S) 272-274, ISSN: 0922-338X, XP002289271
OHARA HITOMI ET AL: "L-Lactic acid production by Bacillus sp. in anaerobic and aerobic culture", 1996, JOURNAL OF FERMENTATION AND BIOENGINEERING, VOL. 81, NR. 3, PAGE(S) 272-274, ISSN: 0922-338X, XP002289271
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