Title:
SELECTING ANIMALS FOR DESIRED GENOTYPIC OR POTENTIAL PHENOTYPIC PROPERTIES BASED ON A SINGLE NUCLEOTIDE POLYMORPHISM (SNP) IN INTRON 3 OF THE IGF2 GENE
Document Type and Number:
WIPO Patent Application WO2004063386
Kind Code:
A3
Abstract:
The invention relates to methods to select animals, such as mammals, in particularly domestic animals such as breeding animals or animals destined for slaughter for having desired genotypic or potential phenotypic properties, in particular related to muscle mass and/or fat deposition or, in the case of mammals, to teat number. The invention provides a method for selecting an animal for having desired genotypic or potential phenotypic properties comprising testing said animal, a parent of said animal or its progeny for the presence of a nucleic acid modification affecting the activity of an evolutionary conserved CpG island, located in intron 3 of an IGF2 gene and/or for the presence of a nucleic acid modification affecting binding of a nuclear factor to an IGF2 gene.
Inventors:
ANDERSSON LEIF (SE)
ANDERSSON GORAN (SE)
GEORGES MICHEL (BE)
BUYS NADINE (BE)
ANDERSSON GORAN (SE)
GEORGES MICHEL (BE)
BUYS NADINE (BE)
Application Number:
PCT/EP2004/000149
Publication Date:
September 30, 2004
Filing Date:
January 09, 2004
Export Citation:
Assignee:
UNIV LIEGE (BE)
MELICA HB (SE)
GENTEC BV (BE)
ANDERSSON LEIF (SE)
ANDERSSON GORAN (SE)
GEORGES MICHEL (BE)
BUYS NADINE (BE)
MELICA HB (SE)
GENTEC BV (BE)
ANDERSSON LEIF (SE)
ANDERSSON GORAN (SE)
GEORGES MICHEL (BE)
BUYS NADINE (BE)
International Classes:
C12Q1/68; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO2000036143A2 | 2000-06-22 |
Other References:
CARICASOLE ANDREA ET AL: "Transactivation of mouse insulin-like growth factor II (IGF-II) gene promoters by the AP-1 complex.", NUCLEIC ACIDS RESEARCH, vol. 21, no. 8, 1993, pages 1873 - 1879, XP001152625, ISSN: 0305-1048
AMARGER V ET AL: "COMPARATIVE SEQUENCE ANALYSIS OF THE INS-IGF2-H19 GENE CLUSTER IN PIGS", MAMMALIAN GENOME, NEW YORK, NY, US, vol. 13, no. 7, July 2002 (2002-07-01), pages 388 - 398, XP009011628, ISSN: 0938-8990
VAN LAERE ANNE-SOPHIE ET AL: "A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig.", NATURE (LONDON), vol. 425, no. 6960, 23 October 2003 (2003-10-23), pages 832 - 836, XP002279572, ISSN: 0028-0836
AMARGER V ET AL: "COMPARATIVE SEQUENCE ANALYSIS OF THE INS-IGF2-H19 GENE CLUSTER IN PIGS", MAMMALIAN GENOME, NEW YORK, NY, US, vol. 13, no. 7, July 2002 (2002-07-01), pages 388 - 398, XP009011628, ISSN: 0938-8990
VAN LAERE ANNE-SOPHIE ET AL: "A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig.", NATURE (LONDON), vol. 425, no. 6960, 23 October 2003 (2003-10-23), pages 832 - 836, XP002279572, ISSN: 0028-0836
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