Title:
PREPARATION METHOD FOR HIGH-STRENGTH SILK PROTEIN NANOFIBER HYDROGEL
Document Type and Number:
WIPO Patent Application WO/2023/137880
Kind Code:
A1
Abstract:
Provided in the present invention is a preparation method for high-strength silk protein nanofiber hydrogel, comprising: freeze-drying an aqueous solution of high-crystallinity silk protein nanofibers and dissolving same in a formic acid solution, loading the solution into a dialysis bag or a semipermeable membrane and replacing the formic acid with the aqueous solution to obtain high-strength silk protein nanofiber hydrogel. In the method provided by the present invention, by means of dissolving high-crystallinity silk protein nanofibers in formic acid, electrostatic repulsion between fibers is reduced and a high-concentration silk protein nanofiber formic acid solution is obtained whilst the original secondary structure and morphology of the nanofibers are kept, thereby enhancing the interaction between the silk protein nanofibers; and then formic acid is removed by means of formic acid solvent replacement with water. The interaction between fibers is fixed by means of a gelation effect of the high-concentration silk protein nanofibers in an aqueous phase, so that the mechanical properties of a final hydrogel material are greatly improved.
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Inventors:
LV QIANG (CN)
ZHANG XIAOYI (CN)
ZHANG XIAOYI (CN)
Application Number:
PCT/CN2022/086039
Publication Date:
July 27, 2023
Filing Date:
April 11, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C08J3/09; C08J3/075; C08L89/00
Foreign References:
| CN112876711A | 2021-06-01 | |||
| CN106139246A | 2016-11-23 | |||
| CN106310380A | 2017-01-11 | |||
| CN107080860A | 2017-08-22 | |||
| CN107118384A | 2017-09-01 | |||
| JP2015093857A | 2015-05-18 |
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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