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Title:
PREPARATION METHOD FOR OXETANE-2-METHYLAMINE
Document Type and Number:
WIPO Patent Application WO/2023/065434
Kind Code:
A1
Abstract:
Provided in the present invention is a preparation method for oxetane-2-methylamine, which belongs to the technical field of organic synthesis. In the present invention, [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and is reacted in the presence of potassium tert-butoxide and trimethyl sulfoxide iodide; the obtained product is then reacted with a sulfonyl compound and triethylamine; the obtained product is subsequently reacted with a phthalamide compound; and finally the obtained product is reacted with an amino-containing compound to obtain oxetane-2-methylamine. According to the preparation method provided in the present invention, the total yield is still 30% or more after amplified production (kilogram level), and the yield is high. Moreover, compared with a traditional preparation method for oxetane-2-methylamine, the preparation method provided in the present invention does not need a palladium-carbon catalytic hydrogenation step, and a dangerous sodium azide product also does not need to be used; and the preparation method has high safety, a low production cost and simple operation, and is suitable for industrial production.

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Inventors:
TIAN YONG (CN)
YANG JUN (CN)
XUE DUOQING (CN)
WU YONG (CN)
CHEN LIHUANG (CN)
Application Number:
PCT/CN2021/130386
Publication Date:
April 27, 2023
Filing Date:
November 12, 2021
Export Citation:
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Assignee:
ACCELA CHEMBIO CO LTD (CN)
International Classes:
C07D305/06; C07D211/40
Domestic Patent References:
WO2017147410A12017-08-31
Foreign References:
CN101061110A2007-10-24
KR20150141275A2015-12-18
US20190382384A12019-12-19
Other References:
FITTON ALAN O. ET AL: "Synthesis of Simple Oxetanes Carrying Reactive 2-Substituents", SYNTHESIS, vol. 12, 31 December 1987 (1987-12-31), pages 1140 - 1142, XP055917215, ISSN: 0090-6883
Attorney, Agent or Firm:
BEIJING FINELAND IP FIRM (CN)
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