Title:
PREPARATION METHODS FOR 3,5-DIHALOBENZOTRIFLUORIDE AND 3'-CHLORO-5'-(TRIFLUOROMETHYL)PHENYLTRIFLUOROETHANONE
Document Type and Number:
WIPO Patent Application WO/2022/061918
Kind Code:
A1
Abstract:
The present application relates to the technical field of chemical pharmacy, and in particular, to a preparation method for 3,5-dihalobenzotrifluoride, comprising: using 3,5-dihalo-4-aminotrifluorotoluene as a raw material, and subjecting same to diazotization deamination reaction to obtain 3,5-dihalobenzotrifluoride. The preparation method has low production cost, and thus has relatively good economic effect. The present application also relates to a preparation method for 3'-chloro-5'-(trifluoromethyl)phenyltrifluoroethanone, wherein 3,5-dihalobenzotrifluoride is used as a raw material, and is subjected to a Grignard reagent reaction, and then undergoes a nucleophilic addition reaction together with a trifluoromethylation reagent. This preparation method also has good economic effect.
Inventors:
ZHANG LINGXIAO (CN)
CAI GANGHUA (CN)
CAI GANGHUA (CN)
Application Number:
PCT/CN2020/118509
Publication Date:
March 31, 2022
Filing Date:
September 28, 2020
Export Citation:
Assignee:
HANGZHOU ABSOBIOTEC CO LTD (CN)
International Classes:
C07C25/13; C07C17/35; C07C45/68; C07C49/80; C07C245/20; C07F3/02
Foreign References:
| CN101990530A | 2011-03-23 | |||
| CN1367695A | 2002-09-04 |
Other References:
ASMUS SÖREN, STEPHAN BECKENDORF, MERCEDES ZURRO, CHRISTIAN MÜCK-LICHTENFELD, ROLAND FRÖHLICH, OLGA GARCIA MANCHENO: "Influence of the Substitution and Conformation of C-H-Bond-Based Bis-Triazole Acceptors in Anion-Binding Catalysis", CHEMISTRY AN ASIAN JOURNAL, vol. 9, no. 8, 31 December 2014 (2014-12-31), XP055913567, DOI: 0.1002/asia.201402237
Attorney, Agent or Firm:
BEIJING WEIZHENG PATENT AGENCY CO., LTD. (CN)
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