Title:
SYNTHESIS METHOD FOR 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
Document Type and Number:
WIPO Patent Application WO/2022/061917
Kind Code:
A1
Abstract:
The present application relates to the technical field of chemical pharmaceutics, and in particular, to a synthesis method for 3',5'-dichloro-2,2,2-trifluoroacetophenone. The method comprises: first reacting 1,3,5-trichlorobenzene or 3,5-dichloro-1-bromobenzene with magnesium to form a Grignard reagent; and then subjecting the Grignard reagent and a trifluoroacetyl reagent to a nucleophilic addition reaction to obtain 3',5'-dichloro-2,2,2-trifluoroacetophenone after acid treatment. The synthesis method has mild reaction conditions, low raw material cost, favorable economic effect, and broad prospects for industrial production.
Inventors:
ZHANG LINGXIAO (CN)
CAI GANGHUA (CN)
TANG HONGYUAN (CN)
CHENG JINTAO (CN)
CAI GANGHUA (CN)
TANG HONGYUAN (CN)
CHENG JINTAO (CN)
Application Number:
PCT/CN2020/118503
Publication Date:
March 31, 2022
Filing Date:
September 28, 2020
Export Citation:
Assignee:
TAIZHOU ABSOBIOTEC CO LTD (CN)
ZHEJIANG JIANGBEI NANHAI PHARMACEUTICAL CO LTD (CN)
ZHEJIANG JIANGBEI NANHAI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C49/80; C07C45/45
Foreign References:
| CN103282345A | 2013-09-04 | |||
| CN103224447A | 2013-07-31 | |||
| CN1605587A | 2005-04-13 | |||
| CN109731610A | 2019-05-10 | |||
| CN102503794A | 2012-06-20 |
Other References:
WANG, YONG ET AL.: "Synthesis of 1,3-Dichloro-5-(3,3,3-Trifluoroprop-1-en-2-yl) Benzene", CHEMICAL REAGENTS, vol. 39, no. 11, 30 November 2017 (2017-11-30), pages 1237 - 1240,1243, XP055913937
GUILLAUME DE NANTEUIL: "A Novel Access to 4-Fluoropyrimidines from a-Chloro-a’-Trifluoromethylketones", TCUAHCDRON LETTERS, vol. 32, no. 22, 31 December 1991 (1991-12-31), pages 2467 - 2468, XP055103524, DOI: 10.1016/S0040-4039(00)74355-3
GUILLAUME DE NANTEUIL: "A Novel Access to 4-Fluoropyrimidines from a-Chloro-a’-Trifluoromethylketones", TCUAHCDRON LETTERS, vol. 32, no. 22, 31 December 1991 (1991-12-31), pages 2467 - 2468, XP055103524, DOI: 10.1016/S0040-4039(00)74355-3
Attorney, Agent or Firm:
BEIJING WEIZHENG PATENT AGENCY CO., LTD. (CN)
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