Title:
PREPARATION AND USE OF RECOMBINANT FIVE-COMPONENT SARS-COV-2 TRIMER PROTEIN VACCINE CAPABLE OF INDUCING BROAD-SPECTRUM NEUTRALIZATION ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2024/032468
Kind Code:
A1
Abstract:
The present invention relates to the field of molecular vaccinology. Provided is a recombinant multi-component SARS-CoV-2 trimer protein vaccine capable of inducing broad-spectrum neutralization activity. The components of a recombinant protein comprise, but are not limited to, a homotrimer protein which is formed by introducing mutation sites and trimerization auxiliary structures into the extracellular domains (ECD) of spike proteins (S protein) of Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2) and Omicron (BA.1, BA.4/BA.5). The multi-component vaccine comprises the ECD trimer protein of a single component or any combined components of the variants and a pharmaceutically acceptable adjuvant. The vaccine combination shows excellent immunogenicity in mice, and can maintain long-term humoral immune and cellular immune responses. The multi-component SARS-CoV-2 trimer protein vaccine can be used for preventing infection-related diseases caused by infection of SARS-CoV-2 and the variants thereof.
Inventors:
XIE LIANGZHI (CN)
SUN CHUNYUN (CN)
ZHANG YANJING (CN)
SUN CHUNYUN (CN)
ZHANG YANJING (CN)
Application Number:
PCT/CN2023/111051
Publication Date:
February 15, 2024
Filing Date:
August 03, 2023
Export Citation:
Assignee:
SINOCELLTECH LTD (CN)
International Classes:
A61K39/215; C07K19/00; A61P31/14; C12N15/62; C12N15/85
Foreign References:
| CN113185613A | 2021-07-30 | |||
| CN113388041A | 2021-09-14 | |||
| US20210246170A1 | 2021-08-12 | |||
| CN114702556A | 2022-07-05 |
Other References:
CHING-LIN HSIEH ET AL.: "Structure-Based Design of Prefusion-Stabilized SARS-CoV-2 Spikes", SCIENCE, vol. 369, no. 6510, 23 July 2020 (2020-07-23), XP055780339, ISSN: 0036-8075, DOI: 10.1126/science.abd0826
Attorney, Agent or Firm:
RUNPING & PARTNERS (CN)
Download PDF: