PREVENTION OF KIDNEY INJURY INDUCED BY HEMOLYTIC REACTION

WIPO Patent Application WO/2022/191193

A1

One of the problems of the present invention is to provide an agent for preventing a kidney injury induced by a hemolytic reaction.　In the present invention, cilastatin or a pharmaceutically acceptable salt thereof is used.

SAITO AKIHIKO (JP)
GOTO SAWAKO (JP)
HIRAYAMA YOSHIAKI (JP)

PCT/JP2022/010031

September 15, 2022

March 08, 2022

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UNIV NIIGATA (JP)
DENKA COMPANY LTD (JP)

A61K31/201; A61P13/12; A61P43/00

WO2015111666A1	2015-07-30
WO2019208777A1	2019-10-31

US20190262321A1	2019-08-29
JP2017535522A	2017-11-30
JP2018524402A	2018-08-30
JP2017531643W

RUBIO-NAVARRO ALFONSO, MARIA DOLORES SANCHEZ-NIÑO, MELANIA GUERRERO-HUE, CRISTINA GARCÍA-CABALLERO, EDUARDO GUTIÉRREZ, CLAUDIA YUS: "Podocytes are new cellular targets of haemoglobin-mediated renal damage", THE JOURNAL OF PATHOLOGY, WILEY, vol. 244, no. 3, 10 January 2018 (2018-01-10), Wiley , pages 296 - 310, XP055966022, ISSN: 1096-9896, DOI: 10.1002/path.5011
ZAGAR ET AL., AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, vol. 311, 2016, pages 640 - 651
HORI ET AL., JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 28, 2017, pages 1783 - 1791
OHARA ET AL., PLOS ONE, vol. 13, no. 1, 2018, pages e0204160
CHRISTENSEN ET AL., MOLECULAR CELL BIOLOGY, vol. 3, 2002, pages 258 - 268

YAMAMOTO, Osamu et al. (JP)

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