Title:
PREVENTION OF RETINOPATHY BY INHIBITION OF THE VISUAL CYCLE
Document Type and Number:
WIPO Patent Application WO2005087210
Kind Code:
A3
Abstract:
The invention relates to compounds capable of inhibiting the visual cycle and/or dark adaptation and their use for treatment and prevention of non-degenerative retinal diseases with specific emphasis on the prevention and treatment of diabetic retinopathy, retinopathy of prematurity, branch retinal vein occlusion, central retinal vein occlusion, open-angle glaucoma, veovascular glaucoma, and other diseases of the retinal and/or optic nerve where an imbalance between metabolic demand and blood supply contribute to the development of tissue damage. The invention furthermore relates to pharmaceutical compositions comprising such compounds.
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Inventors:
LARSEN LARS MICHAEL (DK)
Application Number:
PCT/DK2005/000176
Publication Date:
November 10, 2005
Filing Date:
March 16, 2005
Export Citation:
Assignee:
LARSEN LARS MICHAEL (DK)
International Classes:
A61K31/05; A61K31/07; A61K31/136; A61K31/192; A61K31/203; A61K31/4436; (IPC1-7): A61K31/07; A61K31/05; A61P27/02
Domestic Patent References:
| WO2003004058A1 | 2003-01-16 | |||
| WO2005056010A1 | 2005-06-23 | |||
| WO2005011741A2 | 2005-02-10 |
Foreign References:
| EP0522226A1 | 1993-01-13 | |||
| US20030032078A1 | 2003-02-13 | |||
| US5824685A | 1998-10-20 |
Other References:
WROBEL A ET AL: "Antiangiogenic activity of agonist and antagonists of retinoid nuclear receptors", PRZEGLAD DERMATOLOGICZNY 1999 POLAND, vol. 86, no. 4, 1999, pages 339 - 346, XP000879096, ISSN: 0033-2526
MARMOR M F ET AL: "Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes", RETINA 2003 UNITED STATES, vol. 23, no. 4, 2003, pages 543 - 546, XP008049556, ISSN: 0275-004X
WELEBER R G ET AL: "Abnormal retinal function associated with isotretinoin therapy for acne", ARCHIVES OF OPHTHALMOLOGY 1986 UNITED STATES, vol. 104, no. 6, 1986, pages 831 - 837, XP008049560
CALISSENDORFF B M: "RETINAL CHANGES DEGENERATION OR SIDE EFFECTS CAUSED BY ETRETINATE THERAPY TIGASON", KLINISCHE MONATSBLAETTER FUER AUGENHEILKUNDE, vol. 194, no. 3, 1989, pages 187 - 189, XP008049557, ISSN: 0023-2165
OIKAWA T ET AL: "THREE NOVEL SYNTHETIC RETINOIDS, RE 80, AM 580 AND AM 80, ALL EXHIBIT ANTI-ANGIOGENIC ACTIVITY IN VIVO", EUROPEAN JOURNAL OF PHARMACOLOGY, AMSTERDAM, NL, vol. 249, no. 1, November 1993 (1993-11-01), pages 113 - 116, XP000879175, ISSN: 0014-2999
MARMOR M F ET AL: "Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes", RETINA 2003 UNITED STATES, vol. 23, no. 4, 2003, pages 543 - 546, XP008049556, ISSN: 0275-004X
WELEBER R G ET AL: "Abnormal retinal function associated with isotretinoin therapy for acne", ARCHIVES OF OPHTHALMOLOGY 1986 UNITED STATES, vol. 104, no. 6, 1986, pages 831 - 837, XP008049560
CALISSENDORFF B M: "RETINAL CHANGES DEGENERATION OR SIDE EFFECTS CAUSED BY ETRETINATE THERAPY TIGASON", KLINISCHE MONATSBLAETTER FUER AUGENHEILKUNDE, vol. 194, no. 3, 1989, pages 187 - 189, XP008049557, ISSN: 0023-2165
OIKAWA T ET AL: "THREE NOVEL SYNTHETIC RETINOIDS, RE 80, AM 580 AND AM 80, ALL EXHIBIT ANTI-ANGIOGENIC ACTIVITY IN VIVO", EUROPEAN JOURNAL OF PHARMACOLOGY, AMSTERDAM, NL, vol. 249, no. 1, November 1993 (1993-11-01), pages 113 - 116, XP000879175, ISSN: 0014-2999
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