Title:
超音波増強ナノ粒子媒介性薬物送達のためのエコー形成性マイクロバブルおよびマイクロエマルジョン
Document Type and Number:
Japanese Patent JP2008542293
Kind Code:
A
Abstract:
Described are methods and compositions for treating tumors, such as drug-sensitive tumors, inoperable tumors, poorly vascularized tumors, and multidrug resistant tumors, by intravenous or direct intratumoral injection of compositions comprising microemulsions and polymeric micelle-encapsulated biologically active agents. The methods and compositions also include microemulsions converting into microbubbles in situ upon injection. The methods disclosed optionally including applying a micelle disruption method such as ultrasound. Also disclosed are methodologies of imaging administration of agents in tissues using streams of microemulsions which create microbubbles in situ upon injection. The methods and compositions also include enhancement of tumor treatment through use of microemulsions which create microbubbles in situ, upon injection, as cavitation nuclei. The methods and compositions are also useful in enhancing intracellular drug delivery.
Inventors:
Lapoport, Natalia
Gao, Tsongao
Gao, Tsongao
Application Number:
JP2008513736A
Publication Date:
November 27, 2008
Filing Date:
May 23, 2006
Export Citation:
Assignee:
University of Utah Research Foundation
International Classes:
A61K31/704; A61K9/107; A61K9/12; A61K9/51; A61K31/05; A61K31/095; A61K31/337; A61K31/513; A61K31/5513; A61K31/56; A61K31/565; A61K31/568; A61K31/57; A61K31/573; A61K31/7048; A61K33/24; A61K41/00; A61K47/06; A61K47/34; A61P35/00
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa